Author | Barral Netto, Manoel | |
Author | Cardoso, Silvia Andrade | |
Author | Barral, Aldina Maria Prado | |
Access date | 2018-05-09T18:11:44Z | |
Available date | 2018-05-09T18:11:44Z | |
Document date | 1987 | |
Citation | BARRAL NETTO, M.; CARDOSO, A. A.; BARRAL, A. M. P. Different patterns of disease in two inbred mouse strains infected with a clone of Leishmania mexicana amazonensis. Acta Tropica, v. 44, p. 5-11, 1987. | pt_BR |
ISSN | 0001-706X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26346 | |
Sponsorship | Grant AI-16282 (National Institutes of Health - USA) and from the Conselho Nacional de Desenvolvimento Cientifico e Tecnològico (CNPq-Brasil). | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose cutânea | pt_BR |
Subject in Portuguese | Leishmaniose murina | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Subject in Portuguese | Parasite clones | pt_BR |
Subject in Portuguese | L. mexicana | pt_BR |
Title | Different patterns of disease in two inbred mouse strains infected with a clone of Leishmania mexicana amazonensis | pt_BR |
Type | Article | pt_BR |
Abstract | We have infected BALB/c and C57BL/6 mice with a cloned Leishmania
mexicana amazonensis population, obtained from the "Maria" strain. Progres¬
sion of infection and histopathological examination confirmed the extreme
susceptibility of BALB/c mice and the resistant pattern ofthe C57 BL/6. Anti-
Leishmania antibody titers were higher in BALB/c than in C57BL/6 mice
through the period of infection. Tests of delayed type hypersensitivity reaction
with Leishmania antigens were positive in both strains in the beginning ofthe
infection, but were negative later on in BALB/c mice. Our results are similar to
those obtained with mixed parasite populations, and rule out the possibility of
selection among different parasite subpopulations as responsible for the diver¬
gent course of the disease exhibited by these two strains of mice. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Laboratorio de Imunologia. Salvador, BA, Brasil | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | Murine leishmaniasis | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Clones de parasitas | pt_BR |
Subject | L. mexicana | pt_BR |