| Author | Filardy, Alessandra A. | |
| Author | Pires, Dayana R. | |
| Author | Nunes, Marise P. | |
| Author | Takiya, Christina M. | |
| Author | Lima, Célio G. Freire de | |
| Author | Gomes, Flavia L. Ribeiro | |
| Author | Reis, George A. dos | |
| Access date | 2018-05-10T16:07:02Z | |
| Available date | 2018-05-10T16:07:02Z | |
| Document date | 2010 | |
| Citation | FILARDY, Alessandra A. et al. Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages. J. Immunol, v.185, p.2044-2050, July 2010. | pt_BR |
| ISSN | 0022-1767 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26384 | |
| Language | eng | pt_BR |
| Publisher | American Association of Immunologists | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Neutrófilos Apoptóticos | pt_BR |
| Subject in Portuguese | Fenótipo Regulador | pt_BR |
| Subject in Portuguese | Depuração Pró-Inflamatória | pt_BR |
| Subject in Portuguese | Macrófagos | pt_BR |
| Title | Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages | pt_BR |
| Type | Article | |
| DOI | 10.4049/jimmunol.1000017 | |
| Abstract | Clearance of apoptotic exudate neutrophils (efferocytosis) induces either pro- or anti-inflammatory responses in mouse macrophages depending on host genetic background. In this study, we investigated whether neutrophil efferocytosis induces a stable macrophage phenotype that could be recalled by late restimulation with LPS. Bone marrow-derived macrophages previously stimulated by pro- but not anti-inflammatory neutrophil efferocytosis expressed a regulatory/M2b phenotype characterized by low IL-12 and high IL-10 production following restimulation, increased expression of LIGHT/TNF superfamily 14, Th2-biased T cell responses, and permissive replication of Leishmania major. Induction of regulatory/M2b macrophages required neutrophil elastase activity and was partially dependent on TLR4 signaling. These results suggested that macrophage differentiation to a regulatory phenotype plays a role in resolution of inflammation but could contribute to increased humoral Ab responses and parasite persistence in the infected host. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Saúde e Ambiente na Região Amazônica. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Brasília, DF, Brasil. | pt_BR |
| Subject | Apoptotic Neutrophils | pt_BR |
| Subject | Proinflammatory | pt_BR |
| Subject | Regulatory Phenotype | pt_BR |
| Subject | Macrophages | pt_BR |
| e-ISSN | 1550-6606 | |
| Embargo date | 2030-01-01 | |
