| Author | Almeida, M. Silva | |
| Author | Carvalho, L. O. P. | |
| Author | Silva, A. L. Abreu | |
| Author | d'Escoffier, L. N. | |
| Author | Calabrese, Kátia da Silva | |
| Access date | 2018-05-15T12:32:08Z | |
| Available date | 2018-05-15T12:32:08Z | |
| Document date | 2010 | |
| Citation | ALMEIDA, M. Silva; et al. Leishsmania (Leishmania) amazonensis infection: Muscular involvement in BALB/c and C3H.HeN mice. Experimental Parasitology, v.124, p.315-318, 2010. | pt_BR |
| ISSN | 0014-4894 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26441 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | Protozoários | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Subject in Portuguese | Músculos | pt_BR |
| Title | Leishsmania (Leishmania) amazonensis infection: Muscular involvement in BALB/c and C3H.HeN mice | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.exppara.2009.11.006 | |
| Abstract | Recent studies have provided some insights into Leishsmania (Leishmania) amazonensis muscular infection in dogs, although, muscular disease due to leishmaniasis has been poorly documented. The aim of our study was to evaluate involvement of Leishmania in muscular infection of two distinct mouse strains (BALB/c and C3H.He), with different genetic backgrounds. BALB/c mice, susceptible to Leishmania infection, showed, at the beginning of infection, a great number of infected macrophages among muscle fibers; however, in C3H.He resistant mice, muscle fibers were less damaged than in BALB/c mice, but some parasitized macrophages could be seen among them. A follow up of the infection showed an intense inflammatory infiltrate mainly composed of infected macrophages in BALB/c muscles and the presence of amastigotes within muscle fibers; while C3H.He mice exhibited a moderate inflammatory infiltrate among skeletal muscle fibers and an absence of amastigotes. Total destruction of muscles was observed in BALB/c mice in the late phase of infection (day 90) while C3H.He mice showed a process of muscle repair. We concluded that: (1) the muscles of BALB/c mice were more affected by leishmaniasis than those of C3/H.He mice; (2) Leishmania amastigotes are capable of infecting muscular fibers, as observed in BALB/c mice; (3) as inflammatory infiltrate is less intense in C3H.He mice these animals are capable of restoring muscular fibers. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão. Laboratório de Patologia. São Luis, MA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Leishmania (L.) amazonensis | pt_BR |
| Subject | Camundongos | pt_BR |
| Subject | Protozoan | pt_BR |
| Subject | Mice | pt_BR |
| e-ISSN | 1090-2449 | |
| Embargo date | 2030-01-01 | |
