| Author | Valle, Tânia Zaverucha do | |
| Author | Billecocq, Agnès | |
| Author | Guillemot, Laurent | |
| Author | Alberts, Rudi | |
| Author | Gommet, Céline | |
| Author | Geffers, Robert | |
| Author | Calabrese, Kátia | |
| Author | Schughart, Klaus | |
| Author | Bouloy, Michèle | |
| Author | Montagutelli, Xavier | |
| Author | Panthier, Jean-Jacques | |
| Access date | 2018-05-17T11:46:46Z | |
| Available date | 2018-05-17T11:46:46Z | |
| Document date | 2010 | |
| Citation | VALLE, Tânia Zaverucha do; et al. A New Mouse Model Reveals a Critical Role for Host Innate Immunity in Resistance to Rift Valley Fever. J. Immunol., v.185, p.614606156, Oct. 2010. | pt_BR |
| ISSN | 0022-1767 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26462 | |
| Language | eng | pt_BR |
| Publisher | American Association of Immunologists | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Febre do Vale do Rift | pt_BR |
| Subject in Portuguese | Imunidade inata do hospedeiro | pt_BR |
| Subject in Portuguese | doenças virais | pt_BR |
| Subject in Portuguese | Resitência | pt_BR |
| Subject in Portuguese | doença viral transmitida por artrópodes | pt_BR |
| Title | A new mouse model reveals a critical role for host innate immunity in resistance to Rift Valley fever | pt_BR |
| Type | Article | |
| DOI | 10.4049/jimmunol.1000949 | |
| Abstract | Rift Valley fever (RVF) is an arthropod-borne viral disease repeatedly reported in many African countries and, more recently, in Saudi Arabia and Yemen. RVF virus (RVFV) primarily infects domesticated ruminants, resulting in miscarriage in pregnant females and death for newborns and young animals. It also has the ability to infect humans, causing a feverish syndrome, meningoencephalitis, or hemorrhagic fever. The various outcomes of RVFV infection in animals and humans argue for the existence of host genetic determinants controlling the disease. We investigated the susceptibility of inbred mouse strains to infection with the virulent RVFV ZH548 strain. Compared with classical BALB/cByJ mice, wild-derived Mus m. musculus MBT/Pas mice exhibited earlier and greater viremia and died sooner, a result in sharp contrast with their resistance to infection with West Nile virus and influenza A. Infection of mouse embryonic fibroblasts (MEFs) from MBT/Pas mice with RVFV also resulted in higher viral production. Microarray and quantitative RT-PCR experiments showed that BALB/cByJ MEFs displayed a significant activation of the type I IFN pathway. In contrast, MBT/Pas MEFs elicited a delayed and partial type I IFN response to RVFV infection. RNA interference-mediated inhibition of genes that were not induced by RVFV in MBT/Pas MEFs increased viral production in BALB/cByJ MEFs, thus demonstrating their functional importance in limiting viral replication. We conclude that the failure of MBT/Pas murine strain to induce, in due course, a complete innate immune response is instrumental in the selective susceptibility to RVF. | pt_BR |
| Affilliation | . Institut Pasteur. Unité Génétique Fonctionnelle de la Souris. Paris, France / Centre National de la Recherche Scientifique. Unté de Recherche Aossociée. Paris, France. | pt_BR |
| Affilliation | Institut Pasteur. Unité Génétique Moléculaire des Bunyavirus. Paris, France. | pt_BR |
| Affilliation | Institut Pasteur. Unité Génétique Fonctionnelle de la Souris. Paris, France / Centre National de la Recherche Scientifique. Unité de Recherche Aossociée. Paris, France. | pt_BR |
| Affilliation | Helmholtz Centre for Infection Research. Department of Infection Genetics. Braunschweig, Germany / University of Veterinary Medicine. Hannover. Germany. | pt_BR |
| Affilliation | Institut Pasteur. Animalerie Centrale. Paris, France. | pt_BR |
| Affilliation | Helmholtz Centre for Infection Research. Department of Cell Biology. Array Facility. raunschweig, Germany. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Helmholtz Centre for Infection Research. Department of Infection Genetics. Braunschweig, Germany / University of Veterinary Medicine. Hannover. Germany. | pt_BR |
| Affilliation | Institut Pasteur. Unité Génétique Moléculaire des Bunyavirus. Paris, France. | pt_BR |
| Affilliation | Institut Pasteur. Unité Génétique Fonctionnelle de la Souris. Paris, France / Centre National de la Recherche Scientifique. Unité de Recherche Aossociée. Paris, France. | pt_BR |
| Subject | Rift Valley fever | pt_BR |
| Subject | viral disease | pt_BR |
| Subject | Host Innate Immunity | pt_BR |
| Subject | resitance | pt_BR |
| Subject | New Mouse Model | pt_BR |
| Subject | arthropod-borne viral disease | pt_BR |
| e-ISSN | 1550-6606 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
