Author | Soares, Renata O. A. | |
Author | Echevarria, Aurea | |
Author | Bellieny, Myrtes S. S. | |
Author | Pinho, Rosa T. | |
Author | Leo, Rosa M. M. de | |
Author | Seguins, Wellingon S. | |
Author | Machado, Gérzia M. | |
Author | Cavalheiro, Marilene M. Canto | |
Author | Leon, Leonor L. | |
Access date | 2018-05-17T12:55:05Z | |
Available date | 2018-05-17T12:55:05Z | |
Document date | 2011 | |
Citation | SOARES, Renata O. A. et al. Evaluation of thiosemicarbazones and semicarbazones as potential agents anti-Trypanosoma cruzi. Experimental Parasitology, v.129, p.381–387, Sept. 2011. | pt_BR |
ISSN | 0014-4894 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26467 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Tiossemicarbazonas | pt_BR |
Subject in Portuguese | Semicarbazonas | pt_BR |
Subject in Portuguese | Efeito tripanocida | pt_BR |
Subject in Portuguese | derivados | pt_BR |
Title | Evaluation of thiosemicarbazones and semicarbazones as potential agents anti-Trypanosoma cruzi | pt_BR |
Type | Article | |
DOI | 10.1016/j.exppara.2011.08.019 | |
Abstract | Synthetic thiosemicarbazones and semicarbazones were evaluated for their Trypanosoma cruzi trypomastigotes obtained from LLC-MK2 cell cultures. In general, thiosemicarbazone derivatives were most effective and among them the 4-N-(2'-methoxy styryl)-thiosemicarbazone was chosen, to compare the in vitro effect against amastigotes of T. cruzi lodged in mouse peritoneal and human macrophages. A potent trypanocidal effect was observed that was more pronounced against parasites internalized in human macrophages. A potential target for this compound was also evaluated by measuring the nitric oxide synthase activity through NADPH consumption. A significant decrease in enzyme activity was observed. In contrast to the cytotoxic effect observed with benznidazole, no macrophage toxicity was observed for any of the compounds, indicating that their activity was specific for the parasite forms investigated. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Núcleo de Síntese e Química Medicinal. Seropédica, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Núcleo de Síntese e Química Medicinal. Seropédica, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Semicarbazone/thiosemicarbazone | pt_BR |
Subject | derivatives | pt_BR |
Subject | Tripanocidal effect | pt_BR |
Subject | anti-Trypanosoma cruzi | pt_BR |
e-ISSN | 1090-2449 | |
Embargo date | 2030-01-01 | |
xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |