| Author | Faria, Robson Xavier | |
| Author | Rocha, Leandro Machado | |
| Author | Souza, Eloísa Portugal Barros Silva Soares | |
| Author | Almeida, Fernanda Borges | |
| Author | Fernandes, Caio Pinho | |
| Author | Santos, José Augusto Albuquerque | |
| Access date | 2018-05-24T16:03:29Z | |
| Available date | 2018-05-24T16:03:29Z | |
| Document date | 2018 | |
| Citation | FARIA, Robson Xavier; et al. Molluscicidal activity of Manilkara subsericea (Mart.) dubard on Biomphalaria glabrata (Say, 1818). Acta Tropica, v.178, p.163-168, 2018. | pt_BR |
| ISSN | 0001-706X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26635 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Flavonoides | pt_BR |
| Subject in Portuguese | Sapotaceae | pt_BR |
| Subject in Portuguese | Esquistossomose | pt_BR |
| Subject in Portuguese | Parque Nacional da Restinga de Jurubatiba | pt_BR |
| Title | Molluscicidal activity of Manilkara subsericea (Mart.) dubard on Biomphalaria glabrata (Say, 1818) | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2017.11.012 | |
| Abstract | Schistosomiasis is promoted for species from Schistosoma genus affecting over 200 million people worldwide. Molluscicides are an efficient method to control this disease, being able to reduce intermediate host snail Biomphalaria glabrata number. In function of resistance cases using niclosamide, natural products are promisors to discover new drugs. Manilkara subsericea is endemic to Brazilian sandbanks of Rio de Janeiro State and wide ranges of biological activities. However, there is no studies evaluating its effects as molluscicidal agent. We tested crude extract from leaves of M. subsericea molluscicidal action, as well it ethyl-acetate fraction and isolated substances against B. glabrata. M. subsericea leaves crude extract and ethyl acetate fraction induced 80±4.13% and 86.66±4.59% mortality of adult snails at concentrations of 250ppm after 96h, and their LD50 values were 118.7±1.62 and 23.41±1.15ppm respectively. Isolated substances from M. subsericea were also considered active. Quercetin, myricetin and ursolic acid, at concentration of 100ppm (96h), were able to induce mortality levels of 100%, 80% and 53.33%, respectively. Our results suggest that M. subsericea can be considered promising as a molluscicide agent. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outras Protozooses. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Farmácia. Departamento e Tecnologia Farmacêutica. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Farmácia. Departamento e Tecnologia Farmacêutica. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Amapá. Campus Universitário Marco Zero do Equador. Curso de Farmácia. Laboratório de Nanobiotecnologia Fitofarmacêutica. Macapá, AP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Amapá. Campus Universitário Marco Zero do Equador. Curso de Farmácia. Laboratório de Nanobiotecnologia Fitofarmacêutica. Macapá, AP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental..Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Flavonoids | pt_BR |
| Subject | Guracica | pt_BR |
| Subject | Restinga de Jurubatiba National Park | pt_BR |
| Subject | Sapotaceae | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Triterpene | pt_BR |
| Embargo date | 2030-01-01 | |
