| Author | Moura Neto, Jose Pereira de | |
| Author | Cerqueira, Bruno Antonio Veloso | |
| Author | Santos, Wendell Vilas Boas | |
| Author | Lyra, Isa Menezes | |
| Author | Goncalves, Marilda Souza | |
| Access date | 2018-05-24T16:40:51Z | |
| Available date | 2018-05-24T16:40:51Z | |
| Document date | 2017 | |
| Citation | MOURA NETO, J. P. et al. The DAU Allele and Anti-D Alloimmunization Present With High Frequency in Brazilian Sickle Cell Disease Patients. Journao of Hepatology, v. 6, n. 4, p. 73-80, 2017. | pt_BR |
| ISSN | 1927-1212 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26638 | |
| Sponsorship | Brazilian National Council of Research (CNPq) (3065427/2007-5 and 484457/2007-1) (M.S.G.); the Foundation of Research and Extension of Bahia (FAPESB) (1431040053063; 9073/2007
and 6234/2010) (M.S.G.); and MCD/CNPq/MS-SCTIEDECIT (409800/2006-6) (M.S.G.). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elmer Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença falciforme | pt_BR |
| Subject in Portuguese | Aloimunização anti-D | pt_BR |
| Subject in Portuguese | DIIIa | pt_BR |
| Subject in Portuguese | DAR | pt_BR |
| Subject in Portuguese | Alelos DAU | pt_BR |
| Title | The DAU Allele and Anti-D Alloimmunization Present With High Frequency in Brazilian Sickle Cell Disease Patients | pt_BR |
| Type | Article | pt_BR |
| Abstract | Background: Antigens DIIIa, DAR and DAU are common in people
of African descent and are involved in anti-D alloimmunization.
Sickle cell disease (SCD) patients frequently need blood therapy and
are vulnerable to alloimmunization.
Methods: The study included SCD patients from the Brazilian state
of Bahia, which has the highest incidence of the disease in Brazil; 241
SCD patients and 220 healthy individuals were studied. Alleles were
characterized by PCR-RFLP and PCR-SSP techniques.
Results: The DAU allele was found in 22.3% (43/193) of the SCD
patients. Two (1%) patients had the DIIIa/D wild-type genotype, one
(0.5%) had the DIIIa/D- genotype, 11 (5.7%) had the DAR/D wildtype
genotype and three (1.6%) had the DAR/D- genotype. Two patients
were positive for the 667T>G mutation and the 1136C>T mutation,
one (0.5%) had the genotype DIIIa/DAU, and one (0.5%) had
the genotype DAR/DAU.
Conclusion: There was statistical significance when the allele frequencies
were evaluated among SCD, sickle cell anemia (HbSS)
patients and healthy individuals. The frequencies of the DIIIa, DAR
and DAU alleles among SCD patients differ from those of healthy
individuals from the same population, and a high frequency of the
DAU variant was associated with anti-D alloimmunization in these
patients. | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Faculdade de Farmacia. Manaus, AM, Brasil | pt_BR |
| Affilliation | Universidade do Estado da Bahia. Departamento de Ciencias da Vida. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Faculdade de Farmacia. Manaus, AM, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia, Salvador, BA, Brasil | pt_BR |
| Subject | Sickle cell disease | pt_BR |
| Subject | Anti-D alloimmunization | pt_BR |
| Subject | DIIIa | pt_BR |
| Subject | DAR | pt_BR |
| Subject | DAU alleles | pt_BR |
