| Author | Santos, Marcos André Vannier dos | |
| Author | Fontes, Ana Márcia Suarez | |
| Access date | 2018-05-30T16:32:25Z | |
| Available date | 2018-05-30T16:32:25Z | |
| Document date | 2017 | |
| Citation | SANTOS, M. A. V.; FONTES. A. M. S. Role of polyamines in parasite cell architecture and function. Current Pharmaceutical Design, v. 23, p. 3342-3358, 2017. | pt_BR |
| ISSN | 1381-6128 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26686 | |
| Sponsorship | FAPESB, PROEP/CNPq, PP-SUS and CAPES. MAVS is a CNPq research fellow | pt_BR |
| Language | eng | pt_BR |
| Publisher | Bentham Science Publishers | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Poliaminas | pt_BR |
| Subject in Portuguese | Microscopia eletrônica | pt_BR |
| Subject in Portuguese | Quimioterapia | pt_BR |
| Subject in Portuguese | Putrescina | pt_BR |
| Subject in Portuguese | Doença parasitária | pt_BR |
| Subject in Portuguese | Estratégias terapêuticas | pt_BR |
| Title | Role of Polyamines in Parasite Cell Architecture and Function | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.2174/1381612823666170703163458 | |
| Abstract | In the absence of accessible, effective vaccines, the fight against parasitic disease relies mostly on chemotherapy. Nevertheless, the considerable side effects, high costs and growing number of refractory cases comprise substantial drawbacks. Thus, the search for new antiparasitic compounds remains a high priority. The polyamine biosynthesis, conversion and transport pathways offer different targets for selective chemotherapy. Polyamine analogues and other antagonists may provide tools in the search for new lead compounds. Light and electron microscopy techniques may encompass valuable approaches to elucidate the possible mechanisms of action of different antiparasitic compounds, allowing the identification of subcellular target compartments, presumably establishing the basis for a more rational drug design and/or planning of therapeutic strategies. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outras Protozooses. Rio de Janeiro RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outras Protozooses. Rio de Janeiro RJ, Brasil | pt_BR |
| Subject | Polyamines | pt_BR |
| Subject | Electron microscopy | pt_BR |
| Subject | Chemotherapy | pt_BR |
| Subject | Putrescine | pt_BR |
| Subject | Parasitic disease | pt_BR |
| Subject | Therapeutic strategies | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
