| Author | Scalioni, Letícia de Paula | |
| Author | Silva, Allan Peres da | |
| Author | Miguel, Juliana Custódio | |
| Author | Espírito Santo, Márcia Paschoal do | |
| Author | Marques, Vanessa Alves | |
| Author | Mello, Carlos Eduardo Brandão | |
| Author | Nogueira, Cristiane Alves Villela | |
| Author | Lewis-Ximenez, Lia Laura | |
| Author | Lampe, Elisabeth | |
| Author | Villar, Livia Melo | |
| Access date | 2018-06-05T11:41:15Z | |
| Available date | 2018-06-05T11:41:15Z | |
| Document date | 2017 | |
| Citation | SCALIONI, Letícia de Paula; et al. Lack of Association between Hepatitis C Virus core Gene Variation 70/91aa and Insulin Resistance. International Journal of Molecular Sciences, v.18, n.1444, 10p, July 2017. | pt_BR |
| ISSN | 1661-6596 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26714 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hepatite C | pt_BR |
| Subject in Portuguese | aminoácido | pt_BR |
| Subject in Portuguese | resistência à insulina | pt_BR |
| Subject in Portuguese | mutação do núcleo | pt_BR |
| Title | Lack of Association between Hepatitis C Virus core Gene Variation 70/91aa and Insulin Resistance | pt_BR |
| Type | Article | |
| DOI | 10.3390/ijms18071444 | |
| Abstract | The role of hepatitis C virus (HCV) in insulin resistance (IR) is not fully understood. The aim of this study was to determine the impact of amino acid (aa) substitutions in the core region of HCV according to IR and to identify clinical and laboratory associations. Ninety-two treatment-naive HCV patients were recruited to determine laboratory data and blood cell count. IR was determined using Homeostasis Model Assessment (HOMA) index where IR was defined as HOMA ≥2. HCV RNA load and genotype were determined by Abbott Real time HCV. HCV core region was determined by direct nucleotide sequencing. Bivariate analysis was conducted using HOMA IR ≥2 as a dependent factor. IR prevalence was 43.5% (n = 40), vitamin D sufficiency was found in 76.1% (n = 70) and 72.8% (n = 67) had advanced liver fibrosis. In the bivariate analyses, elevated values of γGT (p = 0.024) and fibrosis staging (p = 0.004) were associated with IR, but IR was not related to core mutations. The presence of glutamine in position 70 was associated with low vitamin D concentration (p = 0.005). In the multivariate analysis, no variable was independently associated with HOMA-IR. In conclusion, lack of association between IR and HCV core mutations in positions 70 and 91 suggests that genetic variability of this region has little impact on IR. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffree Guinle. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | amino acid | pt_BR |
| Subject | core mutation | pt_BR |
| Subject | insulin resistance | pt_BR |
| Subject | hepatitis C | pt_BR |
| e-ISSN | 1422-0067 | |
