Author | Faria, Nieli Rodrigues da Costa | |
Author | Solorzano, Victor Edgar Fiestas | |
Author | Souza, Luiz José de | |
Author | Nogueira, Rita Maria Ribeiro | |
Author | Nogueira, Fernanda de Bruycker | |
Author | Carneiro, Thaís Chouin | |
Author | Simões, Jaqueline Bastos Santos | |
Author | Lima, Monique da Rocha Queiroz | |
Author | Pinto, Luzia Maria de Oliveira | |
Author | Kubelka, Claire Fernandes | |
Author | Heringer, Manoela | |
Author | Azeredo, Elzinandes Leal de | |
Author | Santos, Flávia Barreto dos | |
Access date | 2018-06-07T12:39:31Z | |
Available date | 2018-06-07T12:39:31Z | |
Document date | 2017 | |
Citation | FARIA, Nieli Rodrigues da Costa; et al. Analysis of Clinical and Laboratory Alterations Related to Dengue Case Severity: Comparison between Serotypes 2 and 4 in Brazil. Am. J. Trop. Med. Hyg., v.97, n.1, p.137–145, 2017. | pt_BR |
ISSN | 0002-9637 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26758 | |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Severidade de casos de dengue | pt_BR |
Subject in Portuguese | Serotipos | pt_BR |
Subject in Portuguese | Análise | pt_BR |
Subject in Portuguese | Alterações Clínicas e Laboratoriais | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Analysis of Clinical and Laboratory Alterations Related to Dengue Case Severity: Comparison between Serotypes 2 and 4 in Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.4269/ajtmh.16-0227 | |
Abstract | The increase in severe dengue (SD) cases has caused great impact on public health and has concerned authorities of countries where the disease is endemic and epidemics reach high proportions. The recognition of progression signs of this severe disease during the initial febrile phase can be difficult, since the symptoms are often indistinguishable from other febrile diseases. The aim of this study was to evaluate the clinical manifestations and laboratory findings in patients from two dengue outbreaks and their association with the disease. The study was conducted in patients (n = 153) with signs and symptoms consistent with dengue occurred during two distinct epidemics, 2010 and 2013, in the city of Campos dos Goytacazes, Rio de Janeiro, Brazil. According to the 2009 World Health Organization criteria, patients were classified as dengue without warning signs ([DwoWS] 60.6%, 57/94), dengue with warning signs ([DwWS] 30.9%, 29/94), and SD (4.25%, 4/94). Patients with DwWS/SD presented lower platelet and leukocyte counts and higher transaminase levels when compared with the DwoWS ones. Interestingly, patients from the epidemic of 2010 caused by dengue virus 2 (DENV-2) had lower platelet counts than patients of the 2013 epidemic caused by DENV-4. Furthermore, plasma leakage, gastrointestinal bleeding, and pleural effusion, hallmarks for a more severe disease, were also more frequently observed in those cases. Although previous studies may have extensively reported the wide range of the clinical aspects of dengue, the characterization of DENV-4 is desirable considering the burden of the disease during epidemics, especially for the health units and hospitals performing patient's management. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Hospital dos Plantadores de Cana. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Dengue Case Severity | pt_BR |
Subject | Serotypes 2 | pt_BR |
Subject | Serotypes 4 | pt_BR |
Subject | Brazil | pt_BR |
Subject | Analysis | pt_BR |
Subject | Clinical and Laboratory Alterations | pt_BR |
e-ISSN | 1476-1645 | |
Embargo date | 2030-01-01 | |