| Author | Menezes, Erica Godinho | |
| Author | Reis, Jordana Grazziela Alves Coelho dos | |
| Author | Cardoso, Ludmila Melo | |
| Author | Ribeiro, Ágata Lopes | |
| Author | Gonçalves, Juan Jonathan | |
| Author | Gonçalves, Marco Túlio Porto | |
| Author | Cambraia, Rodrigo Dias | |
| Author | Soares, Eric Bassetti | |
| Author | Silva, Luciana Diniz | |
| Author | Pascoal, Vanessa Peruhype Magalhães | |
| Author | Rios, Maria | |
| Author | Chancey, Caren | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Author | Teixeira, Rosângela | |
| Access date | 2018-06-07T18:46:11Z | |
| Available date | 2018-06-07T18:46:11Z | |
| Document date | 2017 | |
| Citation | MENEZES, Erica Godinho et al. Strategies for serum chemokine/cytokine assessment as biomarkers of therapeutic response in HCV patients as a prototype to monitor immunotherapy of infectious diseases. Antiviral Research, v. 141, p. 19-28, 2017. | pt_BR |
| ISSN | 0166-3542 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26789 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Masson | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | HCV | pt_BR |
| Subject in Portuguese | citocinas | pt_BR |
| Title | Strategies for serum chemokine/cytokine assessment as biomarkers of therapeutic response in HCV patients as a prototype to monitor immunotherapy of infectious diseases | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.antiviral.2017.02.001 | |
| Abstract | In this study, strategies for serum biomarker assessment were developed for therapeutic monitoring of HCV patients. For this purpose, serum chemokine/cytokine levels were measured by cytometric-bead-array in HCV patients, categorized according to immunotherapy response as: non-responder/NR, relapser/REL and sustained-virologic-responder/SVR. The results demonstrated an overall increase of serum chemokine/cytokine levels in HCV patients. In general, therapeutic failure was associated with presence of a predominant baseline proinflammatory pattern with enhanced CCL5/RANTES, IFN-α, IFN-γ along with decreased IL-10 levels in NR and increased IL-6 and TNF in REL. SVR displayed lower baseline proinflammatory status with decreased CXCL8/IL-8, IL-12 and IL-17 levels. The inability to uphold IFN-α levels during immunotherapy was characteristic of NR. Serum chemokine/cytokine signatures further support the deleterious effect of proinflammatory baseline status and the critical role of increased/persistent IFN-α levels to guarantee the sustained virologic response. The prominent baseline proinflammatory milieu observed in NR and REL yielded a restricted biomarker network with small number of neighborhood connections, whereas SVR displayed a network with integrated cytokine connectivity. Noteworthy was that SVR presented a shift towards a proinflammatory pattern upon immunotherapy, assuming a pattern similar to that observed in NR and REL at baseline. Moreover, the immunotherapy guided REL towards a profile similar to SVR at baseline. Analysis of baseline-fold changes during treatment pointed out IFN-α and TNF as high-performance biomarkers to monitor immunotherapy outcome. This knowledge may contribute for novel insights into the treatment and control of the continuous public health threat posed by HCV infection worldwide. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Pós-graduação em Ciências Aplicadas à Saúde do Adulto. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Ambulatório de Hepatites Virais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Ambulatório de Hepatites Virais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Ambulatório de Hepatites Virais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Pós-graduação em Ciências Aplicadas à Saúde do Adulto. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Ambulatório de Hepatites Virais. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Center for Biologics and Evaluation Research. US Food and Drug Administration. Silver Spring, MD, USA. | pt_BR |
| Affilliation | Center for Biologics and Evaluation Research. US Food and Drug Administration. Silver Spring, MD, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Pós-graduação em Ciências Aplicadas à Saúde do Adulto. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Ambulatório de Hepatites Virais. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | HCV | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Chemokines | pt_BR |
| Subject | IFN-α | pt_BR |
| Subject | Biomarkers | pt_BR |
| Embargo date | 2024-01-01 | |
