| Author | Cardoso, Ana Karina Mendes Veloso | |
| Author | Barbosa Junior, Aryon de Almeida | |
| Author | Miguel, Fúlvio Borges | |
| Author | Marcantonio, Elcio | |
| Author | Farina, Marcos | |
| Author | Soares, Glória Dulce de Almeida | |
| Author | Rosa, Fabiana Paim | |
| Access date | 2018-06-08T17:35:55Z | |
| Available date | 2018-06-08T17:35:55Z | |
| Document date | 2006 | |
| Citation | CARDOSO, Ana Karina Mendes Veloso et al. Histomorphometric analysis of tissue responses to bioactive glass implants in critical defects in rat calvaria. Cells Tissues Organs, v. 184, p. 128-137, 2006. | pt_BR |
| ISSN | 1422-6405 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26801 | |
| Language | eng | pt_BR |
| Publisher | Karger Publishers | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Vidro bioativo | pt_BR |
| Subject in Portuguese | Regeneração óssea | pt_BR |
| Subject in Portuguese | Biomateriais | pt_BR |
| Subject in Portuguese | Enxerto aloplástico | pt_BR |
| Title | Histomorphometric analysis of tissue responses to bioactive glass implants in critical defects in rat calvaria | pt_BR |
| Type | Article | |
| DOI | 10.1159/000099619 | |
| Abstract | The aim of this study was to evaluate the osteogenic behavior of two chemically similar bioactive glass products (Biogranand Perioglas) implanted in critical bone defects in rat calvaria. Thirty-six transfixed bone defects of 8 mm diameter were made surgically in adult male Wistar rats. The animals were distributed equally into three groups: Biogran (GI), Perioglas (GII) and without implant material (control; GIII). The morphology and composition of both bioactive glasses were analyzed by scanning electron microscopy and energy-dispersive spectrometry. Tissue specimens were analyzed at the biological time points of 15, 30 and 60 days by optical microscopy and morphometry, demonstrating biocompatibility for the tested materials with moderate chronic inflammation involving their particles. Bone neoformation resulted only as a reparative reaction to an intentionally produced defect and was limited to the defect's edges. No statistically significant differences among the groups were observed. At the scar interstice, abundant deposits of collagenous fibers enveloping the particles were noted. The present results indicated that the bioactive glasses, under the experimental conditions analyzed, did not show osteogenic behavior. | pt_BR |
| Affilliation | Federal University of Bahia. Dentistry Faculty. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Federal University of Bahia. Dentistry Faculty and Health Sciences Institute. Biointeraction Department. Salvador, BA, Brasil. | pt_BR |
| Affilliation | State University of São Paulo. Dental School at Araraquara. Department of Periodontology. Araraquara, SP, Brasil. | pt_BR |
| Affilliation | Biomedical Sciences Institute. São Paulo, SP, Brazil. | pt_BR |
| Affilliation | Federal University of Rio de Janeiro. Metallurgical and Materials Engineering. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Health Sciences Institute. Biointeraction Department. Salvador, BA, Brasil. | pt_BR |
| Subject | Bioactive glass | pt_BR |
| Subject | Bone regeneration | pt_BR |
| Subject | Biomaterials | pt_BR |
| Subject | Aloplastic graft | pt_BR |
