| Author | Oliveira, Danilo Bretas de | |
| Author | Candiani, Talitah Michel Sanchez | |
| Author | Luiz, Ana Paula Moreira Franco | |
| Author | Almeida, Gabriel Magno de Freitas | |
| Author | Abrahão, Jônatas Santos | |
| Author | Rios, Maria | |
| Author | Coimbra, Roney Santos | |
| Author | Kroon, Erna Geessien | |
| Access date | 2018-06-15T13:20:44Z | |
| Available date | 2018-06-15T13:20:44Z | |
| Document date | 2017 | |
| Citation | OLIVEIRA, Danilo Bretas de. Etiological agents of viral meningitis in children from a dengue-endemic area, Southeast region of Brazil. J Neurol Sci., v. 375, p. 390-394, 2017. | pt_BR |
| ISSN | 0022-510X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26905 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | menigite viral | pt_BR |
| Subject in Portuguese | diagnostico molecular | pt_BR |
| Subject in Portuguese | epidemiologia | pt_BR |
| Subject in Portuguese | dengue | pt_BR |
| Title | Etiological agents of viral meningitis in children from a dengue-endemic area, Southeast region of Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jns.2017.02.025 | |
| Abstract | Meningitis is a disease with a global distribution that constitutes aworldwide burden,with viruses as the primary etiologic agents. The range of viral meningitis severity depends mainly on age, immune status and etiological agent. The aimof this workwas to investigate the suspected cases of viral meningitis using molecular techniques to confirm the viral infection. The diagnosed virus was correlated with clinical findings and cytochemical parameters in cerebrospinal liquid (CSF) of patients. CSF of 70 children with the presumptive diagnosis of viral meningitis was analyzed by real time PCR (qPCR). Viruses were identified by qPCR in 44 CSF samples (62.9%).
Among them, 31 were identified as Enterovirus (ENTV) (70.4%), six as Human herpes virus 3 (HHV-3) (13.6%), five as Dengue virus (DENV) (11.7%), one as Human herpes virus 1–2 (2.3%) and one as Human herpes virus 5 (2.3%). Patients in the HHV-positive groups had increased percentage of polymorphonuclear neutrophils (PMN) (mean of 81%) while the groups of patients with DENV and ENTV had a mean of 30.9%.
This study contributes to the knowledge of the epidemiological distribution of viral agents in CNS infections in children. In addition, it raises the relevance of DENV as an agent of CNS infection, and reinforces the importance for molecular in the cases of CNV infection. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil /Universidade Federal dos Vales do Jequitinhonha e Mucuri. Faculdade de Medicina de Diamantina. Diamantina, MG, Brazil | pt_BR |
| Affilliation | Fundação Hospitalar do Estado de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Center for Biologics Research and Review. Food and Drug Administration. Silver Spring, MD, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Neurogenômica. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Viral meningitis | pt_BR |
| Subject | Molecular diagnosis | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Dengue virus in CNS | pt_BR |
| Embargo date | 2023-01-01 | |
