| Author | Silva, Fernanda Fonseca | |
| Author | Inacio, Job D. F. | |
| Author | Cavalheiro, Marilene M. Canto | |
| Author | Amaral, Elmo E. Almeida | |
| Access date | 2018-06-26T14:09:27Z | |
| Available date | 2018-06-26T14:09:27Z | |
| Document date | 2013 | |
| Citation | SILVA, Fernanda Fonseca; et al. Reactive Oxygen Species Production by Quercetin Causes the Death of Leishmania amazonensis Intracellular Amastigotes. J. Nat. Prod. v.76, p.1505−1508, July 2013. | pt_BR |
| ISSN | 0163-3864 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27111 | |
| Language | eng | pt_BR |
| Publisher | American Chemical Society | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | Quercetina | pt_BR |
| Subject in Portuguese | atividade antileishmanial | pt_BR |
| Subject in Portuguese | Tratamento | pt_BR |
| Title | Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes | pt_BR |
| Type | Article | |
| DOI | 10.1021/np400193m | |
| Abstract | The present study reports the mechanism of the antileishmanial activity of quercetin against the intracellular amastigote form of Leishmania amazonensis. Treatment with 1 reduced the infection index in L. amazonensis-infected macrophages in a dose-dependent manner, with an IC₅₀ value of 3.4 μM and a selectivity index of 16.8, and additionally increased ROS generation also in a dose-dependent manner. Quercetin has been described as a pro-oxidant that induces the production of reactive oxygen species, which can cause cell death. Taken together, these results suggest that ROS production plays a role in the mechanism of action of 1 in the control of intracellular amastigotes of L. amazonensis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | antileishmanial activity | pt_BR |
| Subject | quercetin | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| Subject | Treatment | pt_BR |
| e-ISSN | 1520-6025 | |
