| Author | Inacio, Job D. F. | |
| Author | Cavalheiro, Marilene M. Canto | |
| Author | Amaral, Elmo E. Almeida | |
| Access date | 2018-06-26T16:06:21Z | |
| Available date | 2018-06-26T16:06:21Z | |
| Document date | 2013 | |
| Citation | INACIO, Job D. F.; CAVALHEIRO, Marilene M. Canto; AMARAL, Elmo E. Almeida. In Vitro and in Vivo Effects of (−)-Epigallocatechin 3‑O‑gallate on Leishmania amazonensis. J. Nat. Prod.m v.76, p.1993−1996, Oct. 2013. | pt_BR |
| ISSN | 0163-3864 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27117 | |
| Language | eng | pt_BR |
| Publisher | American Chemical Society | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | In vitro | pt_BR |
| Subject in Portuguese | In vivo | pt_BR |
| Title | In vitro and in vivo effects of (-)-epigallocatechin 3-O-gallate on Leishmania amazonensis | pt_BR |
| Type | Article | |
| DOI | 10.1021/np400624d | |
| Abstract | (-)-Epigallocatechin 3-O-gallate (1), the most abundant flavanol in green tea, has been reported to have antiproliferative effects on Trypanosoma cruzi. The present study reports the effects in vitro and in vivo of 1 on Leishmania amazonensis. L. amazonensis-infected macrophages treated with 1 exhibited a significant reduction of the infection index in a dose-dependent manner, with an IC50 value of 1.6 μM. Oral administration of 1 on L. amazonensis-infected BALB/c mice (30 mg/kg/day) resulted in a decrease in the lesion size and parasite burden, without altering serological markers of toxicity. These data demonstrate the in vitro and in vivo leishmanicidal effects of compound 1. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| Subject | In vitro | pt_BR |
| Subject | In vivo | pt_BR |
| Subject | Epigallocatechin 3‑O‑gallate | pt_BR |
| e-ISSN | 1520-6025 | |
| Embargo date | 2030-01-01 | |
