Author | Bafica, Aline Michelle Barbosa | |
Author | Cardoso, Luciana Santos | |
Author | Oliveira, Sérgio Costa | |
Author | Loukas, Alex | |
Author | Varela, Giuseppe Tittoni | |
Author | Oliveira, Ricardo Riccio | |
Author | Bacellar, Olívia | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Araújo, Maria Ilma | |
Access date | 2018-06-28T13:16:05Z | |
Available date | 2018-06-28T13:16:05Z | |
Document date | 2011 | |
Citation | BAFICA, A. M. B. et al. Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 856-863, 2011. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27160 | |
Description | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | MCT/CNPq (479417/2008 3 universal) MIA, SCO and EMC are investigators supported by CNPq. | pt_BR |
Language | eng | pt_BR |
Publisher | Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose cutânea | pt_BR |
Subject in Portuguese | Antígenos de S. mansoni | pt_BR |
Subject in Portuguese | Sm29 | pt_BR |
Subject in Portuguese | SmTSP-2 | pt_BR |
Subject in Portuguese | PIII | pt_BR |
Title | Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis | pt_BR |
Type | Article | pt_BR |
Abstract | Schistosoma mansoni infection or associated products are able to down-modulate the type 1 CD4+ T cell inflammatory response characteristic of autoimmune diseases. In this study, we evaluated how S. mansoni antigens altered the immune response that was induced by the soluble Leishmania antigen (SLA) from cutaneous leishmaniasis (CL) patients. Cytokines were measured from the supernatants of peripheral blood mononuclear cell cultures stimulated with SLA. This was performed using the sandwich enzyme linked immunosorbent assay technique in the presence or absence of S. mansoni recombinant antigens Sm29, SmTSP-2 and PIII. The addition of S. mansoni antigens to the cultures resulted in the reduction of interferon gamma (IFN-γ) levels in 37-50% of patients. Although to a lesser extent, the antigens were also able to decrease the production of tumour necrosis factor-alpha (TNF-α). We compared patients that either had or did not have reduction in IFN-γ and TNF-α production in cultures stimulated with SLA in the presence of S. mansoni antigens. We found that there was no significant difference in the levels of interleukin (IL)-10 and IL-5 in response to S. mansoni antigens between the groups. The antigens used in this study down-modulated the in vitro proinflammatory response induced by SLA in a group of CL patients through a currently undefined mechanism. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | University of Edinburgh. Center for Immunity, Infection and Evolution. Edinburgh, UK | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | S. mansoni antigens | pt_BR |
Subject | Sm29 | pt_BR |
Subject | SmTSP-2 | pt_BR |
Subject | PIII | pt_BR |