| Author | Oliveira, Ricardo Riccio | |
| Author | Figueiredo, Joanemile Pacheco de | |
| Author | Cardoso, Luciana Santos | |
| Author | Jabar, Rafael Lessa | |
| Author | Souza, Robson P | |
| Author | Wells, Martin T | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Author | Fitzgerald, Daniel W | |
| Author | Barnes, Kathleen C | |
| Author | Araújo, Maria Ilma Andrade Santos | |
| Author | Glesby, Marshall J | |
| Access date | 2018-06-29T17:23:51Z | |
| Available date | 2018-06-29T17:23:51Z | |
| Document date | 2012 | |
| Citation | OLIVEIRA, R. R. et al. Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil. American Journal of Tropical Medicine and Hygiene, v. 86, n. 2, p. 296–305, 2012. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27204 | |
| Description | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Sponsorship | Brazilian National Research Council (CNPq) Universal (482064/2010-2). Ricardo R. Oliveira and Marshall J. Glesby were supported in part by the Fogarty/Ellison International Clinical Research Scholars Program
and National Institutes of Health/National Institutes of Allergy and Infectious Diseases grant K24Al078884. | pt_BR |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Esquistosomose | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Subject in Portuguese | Fatores socioeconômico | pt_BR |
| Title | Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.4269/ajtmh.2012.11-0204 | |
| Abstract | Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult worm antigen (SWAP) and against interleukin-4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Cornell University. Department of Biological Statistics and Computational Biology. Ithaca, NY | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana deMedicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacionalde Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
| Affilliation | Weill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. Department of Medicine. New York, NY | pt_BR |
| Affilliation | Johns Hopkins University. Department of Medicine. Division of Allergy and Clinical Immunology. Baltimore, MD | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
| Affilliation | Weill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. Department of Medicine. New York, NY | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Humans | pt_BR |
| Subject | Socioeconomic factors | pt_BR |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
