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AutorGrant, A. V.
AutorAraujo, Maria Ilma Andrade Santos
AutorPonte, Eduardo Vieira
AutorOliveira, Ricardo Riccio
AutorCruz, Alvaro Augusto Souza da
AutorBarnes, K. C.
AutorBeaty, Terri H.
Data de acesso2018-07-05T14:14:06Z
Data de disponibilização2018-07-05T14:14:06Z
Data do publicação2011
CitaçãoGRANT, A. V. et al. Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population. Genes and Immunity, v. 12, p. 46–50, 2011.pt_BR
ISSN1466-4879pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/27309
DescriçãoOliveira, Ricardo Riccio. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.pt_BR
FomentoGlaxo-Smith-Kline under the project WE445 entitled ‘Immunogenetics of Schistosomiasis and Asthma,’ and NIH grant # AI050024. KCB was supported in part by the Mary Beryl Patch Turnbull Scholar Program.pt_BR
Idiomaengpt_BR
EditorNature Publishing Grouppt_BR
Direito Autoralrestricted accesspt_BR
Palavras-chaveIgEpt_BR
Palavras-chaveIL-10pt_BR
Palavras-chaveEsquistossomosept_BR
Palavras-chaveAtopiapt_BR
Palavras-chavePolimorfismo promotorpt_BR
Palavras-chaveSuscetibilidade genéticapt_BR
TítuloPolymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian populationpt_BR
Tipo do documentoArticle
DOI10.1038/gene.2010.50
Resumo em InglêsInterleukin (IL)-10 is a regulatory cytokine of the helper T cell type 2 (TH2) pathway, which underlies both the host defense to helminthic infection and atopic diseases, including asthma. Although IL10 promoter polymorphisms are associated with increased atopy risk, IL10 variation has not been thoroughly explored in schistosomiasis-endemic populations. Three atopy-related IL10 promoter polymorphisms (rs1800896, rs1800871 and rs1800872), complemented by six tagging single-nucleotide polymorphisms (SNPs), were genotyped in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area in Brazil. Associations between markers and total serum Immunoglobulin E (tIgE) levels, indicating non-specific activation of the TH2 pathway, and Schistosoma mansoni fecal egg counts, indicating burden of infection reflecting effectiveness of schistosomiasis host immunity, were performed using family-based transmission disequilibrium tests for quantitative traits (QTDTs). Alleles A, T and A at the three promoter SNPs rs1800896, rs1800871 and rs1800872 were associated with high tIgE levels in the same direction as in atopy populations (P=0.0008, 0.026 and 0.045), but not with egg counts. IL10 promoter polymorphisms appear to influence non-specific tIgE levels, but not schistosomiasis-specific immunity. The tagging SNP rs3024495 was associated with high S. mansoni egg counts (P=0.005), suggesting a novel locus in IL10 may influence clinically relevant burden of infection.pt_BR
AfiliaçãoThe Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, USA.pt_BR
AfiliaçãoFederal University of Bahia School of Medicine. ProAR. Salvador, BA, Brasil.pt_BR
AfiliaçãoUniversidade Federal da Bahia. Hospital Universitário Professor Edgard .Santos. Serviço de Imunologia. Salvador, BA, Brasil.pt_BR
AfiliaçãoFederal University of Bahia School of Medicine. ProAR. Salvador, BA, Brasil.pt_BR
AfiliaçãoUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. ProAR. Salvador, BA, Brasil.pt_BR
AfiliaçãoThe Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, USA.pt_BR
AfiliaçãoThe Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, USA.pt_BR
Palavras-chave em inglêsIgEpt_BR
Palavras-chave em inglêsIL-10pt_BR
Palavras-chave em inglêsSchistosomiasispt_BR
Palavras-chave em inglêsAtopypt_BR
Palavras-chave em inglêsPromoter polymorphismpt_BR
Palavras-chave em inglêsGenetic susceptibilitypt_BR


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