| Author | Silveira, Melise Chaves | |
| Author | Catanho, Marcos | |
| Author | Miranda, Antonio Basílio de | |
| Access date | 2018-07-10T14:22:18Z | |
| Available date | 2018-07-10T14:22:18Z | |
| Document date | 2018 | |
| Citation | SILVEIRA, Melise Chaves; CATANHO, Marcos/ MIRANDA, Antônio Basílio de. Genomic analysis of bifunctional Class C-Class D b-lactamases in environmental bacteria. Mem Inst Oswaldo Cruz, v.113, n.8, e180098, 2018. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27399 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vigilância Sanitária | pt_BR |
| Subject in Portuguese | Resistência Microbiana a Medicamentos | pt_BR |
| Title | Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-02760180098 | |
| Abstract | β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional β-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional β-lactamases are widespread in nature; these findings also raise concern that bifunctional β-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | bifunctional b-lactamase | pt_BR |
| Subject | antibiotic resistance | pt_BR |
| Subject | health surveillance | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
