| Author | Cardillo, Fabíola | |
| Author | Postol, Edilberto | |
| Author | Nihei, Jorge Sadao | |
| Author | Aroeira, Luiz S | |
| Author | Nomizo, Auro | |
| Author | Mengele Junior, José Orivaldo | |
| Access date | 2011-07-06T17:31:24Z | |
| Available date | 2011-07-06T17:31:24Z | |
| Document date | 2007 | |
| Citation | CARDILLO, F. et al. B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection. Immunology, v.122, n.4, p.584-595, 2007. | pt_BR |
| ISSN | 0019-2805 | |
| URI | https://www.arca.fiocruz.br/handle/icict/2748 | |
| Language | eng | pt_BR |
| Rights | open access | en |
| Subject in Portuguese | Trypanosoma Cruzi | pt_BR |
| Subject in Portuguese | Células B | pt_BR |
| Subject in Portuguese | IFN-y | pt_BR |
| Subject in Portuguese | Memória | pt_BR |
| Subject in Portuguese | CD8 | pt_BR |
| Title | B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1111/j.1365-2567.2007.02677.x | |
| Abstract | In this study, we have evaluated the production of pro- and anti-inflammatory
cytokines and the formation of central and effector memory T
cells in mice lacking mature B cells (muMT KO). The results show that
Trypanosoma cruzi infection in C57Bl/6ml MT KO mice is intensified in
relation to control mice and this exacerbation is related to low levels of
inflammatory cytokines produced during the acute infection and the
lower numbers of central and effector memory CD4+ and CD8+ T cells
generated during the acute phase of the infection. In addition, a marked
reduction in the CD8+ T-cell subpopulation was observed in muMT KO
infected mice. In agreement to this, the degree of tissue parasitism was
increased in muMT mice and the tissue inflammatory response was much
less intense in the acute phase of the infection, consistent with a deficit in
the generation of effector T cells. Flow cytometry analysis of the skeletal
muscle inflammatory infiltrate showed a predominance of CD8+ CD45Rb
low in B-cell-sufficient C57Bl/6 mice, whereas the preponderant cell type
in muMT KO skeletal muscle inflammatory infiltrate was CD4+ T cells. In
addition, CD8+ T cells found in skeletal muscle from muMT KO infected
mice were less activated than in control B-cell sufficient infected mice.
These results suggest that B cells may participate in the generation of
effector/memory T cells. In addition and more importantly, B cells were
crucial in the maintenance of central and effector memory CD8+ T cell,
as well as the determination of the T cell cytokine functional pattern, and
they may therefore account for critical aspects of the resistance to intracellular
pathogens, such as T. cruzi. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Instituto do Coração. Universidade de São Paulo. Laboratório de Imunologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital La Paz. Unidad de Investigacion. Madrid, ESP, Espanha | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicologia e Bromatologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, Brasil | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | B cells | pt_BR |
| Subject | IFN-y | pt_BR |
| Subject | Memory | pt_BR |
| Subject | CD8 | pt_BR |
| DeCS | Trypanosoma cruzi | pt_BR |
| DeCS | Linfócitos B | pt_BR |
| DeCS | Interferon gama | pt_BR |
| DeCS | Memória | pt_BR |
| DeCS | Antígenos CD8 | pt_BR |
