| Author | Cardoso, Luciana Santos | |
| Author | Oliveira, Sergio Costa | |
| Author | Góes, Alfredo Miranda de | |
| Author | Oliveira, Ricardo Riccio | |
| Author | Pacífico, Lucila Grossi Gonçalves | |
| Author | Marinho, Fábio Antônio Vitarelli | |
| Author | Fonseca, Cristina Toscano | |
| Author | Cardoso, Fernanda Caldas | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Author | Araujo, Maria Ilma Andrade Santos | |
| Access date | 2018-07-12T13:53:30Z | |
| Available date | 2018-07-12T13:53:30Z | |
| Document date | 2010 | |
| Citation | Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation | pt_BR |
| ISSN | 0009-9104 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27505 | |
| Description | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Sponsorship | Brazilian National Research Council (CNPq). M. I. A., S. C. O. and E. M. C. are investigators supported by CNPq. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Alergia | pt_BR |
| Subject in Portuguese | Asma | pt_BR |
| Subject in Portuguese | Vacinas | pt_BR |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Title | Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1111/j.1365-2249.2009.04084.x | |
| Abstract | Schistosoma mansoni infection has been associated with protection against allergies. The mechanisms underlying this association may involve regulatory cells and cytokines. We evaluated the immune response induced by the S. mansoni antigens Sm22.6, PIII and Sm29 in a murine model of ovalbumin (OVA)-induced airway inflammation. BALB/c mice were sensitized with subcutaneously injected OVA-alum and challenged with aerolized OVA. Mice were given three doses of the different S. mansoni antigens. Lung histopathology, cellularity of bronchoalveolar lavage (BAL) and eosinophil peroxidase activity in lung were evaluated. Immunoglobulin (Ig)E levels in serum and cytokines in BAL were also measured. Additionally, we evaluated the frequency of CD4+forkhead box P3 (FoxP3)+ T cells in cultures stimulated with OVA and the expression of interleukin (IL)-10 by these cells. The number of total cells and eosinophils in BAL and the levels of OVA-specific IgE were reduced in the immunized mice. Also, the levels of IL-4 and IL-5 in the BAL of mice immunized with PIII and Sm22.6 were decreased, while the levels of IL-10 were higher in mice immunized with Sm22.6 compared to the non-immunized mice. The frequency of CD4+FoxP3+ T cells was higher in the groups of mice who received Sm22.6, Sm29 and PIII, being the expression of IL-10 by these cells only higher in mice immunized with Sm22.6. We concluded that the S. mansoni antigens used in this study are able to down-modulate allergic inflammatory mediators in a murine model of airway inflammation and that the CD4+FoxP3+ T cells, even in the absence of IL-10 expression, might play an important role in this process. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
| Subject | Allergy | pt_BR |
| Subject | Asthma | pt_BR |
| Subject | Vaccines | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
