| Author | Almeida, Fausto | |
| Author | Wolf, Julie M | |
| Author | da Silva, Thiago Aparecido | |
| Author | DeLeon-Rodriguez, Carlos M | |
| Author | Rezende, Caroline Patini | |
| Author | Pessoni, André Moreira | |
| Author | Fernandes, Fabrício Freitas | |
| Author | Silva-Rocha, Rafael | |
| Author | Martinez, Roberto | |
| Author | Rodrigues, Marcio Lourenço | |
| Author | Roque-Barreira, Maria Cristina | |
| Author | Casadevall, Arturo | |
| Access date | 2018-07-26T13:39:30Z | |
| Available date | 2018-07-26T13:39:30Z | |
| Document date | 2017 | |
| Citation | ALMEIDA, F. et al. Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects. Nature Communications, v. 8, p. 1968, 2017. | pt_BR |
| ISSN | 2041-1723 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27670 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | galectina | pt_BR |
| Subject in Portuguese | criptococcose | pt_BR |
| Title | Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1038/s41467-017-02126-7 | |
| Abstract | Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian β-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in C. neoformans infection. We find augmented Gal-3 serum levels in human and experimental infections, as well as in spleen, lung, and brain tissues of infected mice. Gal-3-deficient mice are more susceptible to cryptococcosis than WT animals, as demonstrated by the higher fungal burden and lower animal survival. In vitro experiments show that Gal-3 inhibits fungal growth and exerts a direct lytic effect on C. neoformans extracellular vesicles (EVs). Our results indicate a direct role for Gal-3 in antifungal immunity whereby this molecule affects the outcome of C. neoformans infection by inhibiting fungal growth and reducing EV stability, which in turn could benefit the host. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | Yeshiva University. Albert Einstein College of Medicine. Department of Microbiology and Immunology. New York, NY, EUA. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | Yeshiva University. Albert Einstein College of Medicine. Department of Microbiology and Immunology. New York, NY, EUA. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School . Department of Internal Medicine. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil. | pt_BR |
| Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology. Baltimore, MD, EUA. | pt_BR |
