| Author | Shivakoti, Rupak | |
| Author | Gupte, Nikhil | |
| Author | Yang, Wei-Teng | |
| Author | Mwelase, Noluthando | |
| Author | Kanyama, Cecilia | |
| Author | Tang, Alice M. | |
| Author | Pillay, Sandy | |
| Author | Samaneka, Wadzanai | |
| Author | Riviere, Cynthia | |
| Author | Berendes, Sima | |
| Author | Lama, Javier R. | |
| Author | Cardoso, Sandra W. | |
| Author | Sugandhavesa, Patcharaphan | |
| Author | Semba, Richard D. | |
| Author | Christian, Parul | |
| Author | Campbell, Thomas B. | |
| Author | Gupta, Amita | |
| Access date | 2018-07-31T17:22:28Z | |
| Available date | 2018-07-31T17:22:28Z | |
| Document date | 2014 | |
| Citation | SHIVAKOTI, Rupak et al. Pre-Antiretroviral Therapy Serum Selenium Concentrations Predict WHO Stages 3, 4 or Death but not Virologic Failure Post-Antiretroviral Therapy. Nutrients, v. 6, p. 5061-5078, 2014. | pt_BR |
| ISSN | 2072-6643 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27738 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Pre-antiretroviral therapy serum selenium concentrations predict WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3390/nu6115061 | |
| Abstract | A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus (HIV) disease progression after ART initiation. Cases were HIV-1 infected adults with either clinical failure (incident World Health Organization (WHO) stage 3, 4 or death by 96 weeks) or virologic failure by 24 months. Risk factors for serum selenium deficiency (<85 μg/L) pre-ART and its association with outcomes were examined. Median serum selenium concentration was 82.04 μg/L (Interquartile range (IQR): 57.28-99.89) and serum selenium deficiency was 53%, varying widely by country from 0% to 100%. In multivariable models, risk factors for serum selenium deficiency were country, previous tuberculosis, anemia, and elevated C-reactive protein. Serum selenium deficiency was not associated with either clinical failure or virologic failure in multivariable models. However, relative to people in the third quartile (74.86-95.10 μg/L) of serum selenium, we observed increased hazards (adjusted hazards ratio (HR): 3.50; 95% confidence intervals (CI): 1.30-9.42) of clinical failure but not virologic failure for people in the highest quartile. If future studies confirm this relationship of high serum selenium with increased clinical failure, a cautious approach to selenium supplementation might be needed, especially in HIV-infected populations with sufficient or unknown levels of selenium. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, MD, USA. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, MD, USA. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, MD, USA. | pt_BR |
| Affilliation | University of Witwatersrand. Department of Medicine. Johannesburg, South Africa. | pt_BR |
| Affilliation | University of North Carolina Lilongwe. Lilongwe, Malawi. | pt_BR |
| Affilliation | Tufts University School of Medicine. Department of Public Health and Community Medicine. Boston, MA, USA. | pt_BR |
| Affilliation | Durban University of Technology. Durban International Clinical Research Site. Durban, South Africa. | pt_BR |
| Affilliation | University of Zimbabwe Clinical Research Centre. Harare, Zimbabwe. | pt_BR |
| Affilliation | Les Centres GHESKIO. Port-Au-Prince, Haiti. | pt_BR |
| Affilliation | Liverpool School of Tropical Medicine. International Public Health Department. Liverpool, UK. | pt_BR |
| Affilliation | Asociacion Civil Impacta Salud y Educacion. Lima, Peru. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Research Institute for Health Sciences. Chiang Mai, Thailand. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Ophthalmology. Baltimore, MD, USA. | pt_BR |
| Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of International Health. Baltimore, MD, USA. | pt_BR |
| Affilliation | University of Colorado School of Medicine. Department of Medicine, Division of Infectious Diseases. Aurora. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, MD, USA. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Selenium | pt_BR |
| Subject | Antiretroviral therapy | pt_BR |
| Subject | Nutrition | pt_BR |
| Subject | Treatment failure | pt_BR |
| Subject | Cohort studies | pt_BR |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
