| Author | Quinnell, Rupert J. | |
| Author | Pullan, Rachel L. | |
| Author | Breitling, Lutz Ph. | |
| Author | Geiger, Stefan Michael | |
| Author | Cundill, Bonnie | |
| Author | Oliveira, Rodrigo Correa de | |
| Author | Brooker, Simon | |
| Author | Bethony, Jeffrey Michael | |
| Access date | 2018-08-01T16:04:42Z | |
| Available date | 2018-08-01T16:04:42Z | |
| Document date | 2010 | |
| Citation | QUINNELL, Rupert J. et al. Genetic and Household Determinants of Predisposition to Human Hookworm Infection in a Brazilian Community. J Infect Dis., v. 202, n. 6, p. 954–961, Sept. 15, 2010. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27766 | |
| Language | eng | pt_BR |
| Publisher | University of Chicago Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Hereditariedade | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Predisposição | pt_BR |
| Subject in Portuguese | Resistência | pt_BR |
| Subject in Portuguese | Análise de componentes de variância | pt_BR |
| Subject in Portuguese | Necator americanus | pt_BR |
| Title | Genetic and Household Determinants of Predisposition to Human Hookworm Infection in a Brazilian Community | pt_BR |
| Type | Article | |
| DOI | 10.1086/655813 | |
| Abstract | Background: Predisposition to heavy or light human hookworm infection is consistentlyreported in treatment-reinfection studies. A significant role for host genetics in determining hookworm infection intensity has also been shown, but the relationship between host genetics and predisposition has not been investigated.
Methods: A treatment-reinfection study was carried out on 1302 individuals in Brazil. Bivariate variance components analysis was used to estimate heritability for pretreatment and reinfection intensity, and to estimate the contribution of genetic and household correlations between phenotypes to the overall phenotypic correlation (i.e. predisposition).
Results: Heritability for hookworm egg count was 17% pretreatment and 25% after reinfection. Predisposition to heavy or light hookworm infection was observed, with a phenotypic correlation of 0.34 between pretreatment and reinfection intensity. This correlation was reduced to 0.23 after including household and environmental covariates. Genetic and household correlations were 0.41 and 1 respectively, and explained 88% of the adjusted phenotypic correlation.
Conclusions: Predisposition to human hookworm infection in this area results from a combination of host genetics and consistent differences in exposure, with the latter explained by household and environmental factors. Unmeasured individual-specific differences in exposure did not contribute to predisposition. | pt_BR |
| Affilliation | Institute of Integrative and Comparative Biology. University of Leeds. Leeds, London, UK. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, UK. | pt_BR |
| Affilliation | Institute of Integrative and Comparative Biology. University of Leeds. Leeds, London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil / The George Washington University. Washington D.C., USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom / Malaria Public Health and Epidemiology Group. KEMRI-Wellcome Trust Research Programme. Nairobi, Kenya. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil / The George Washington University. Washington D.C., USA. | pt_BR |
| Subject | Heritability | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Predisposition | pt_BR |
| Subject | Resistance | pt_BR |
| Subject | Variance components analysis | pt_BR |
| Subject | Necator americanus | pt_BR |
| Embargo date | 2025-01-01 | |
