| Author | Calvet, Guilherme Amaral | |
| Author | Kara, Edna Oliveira | |
| Author | Giozza, Silvana Pereira | |
| Author | Menezes, Camila Helena Aguiar Bôtto | |
| Author | Gaillard, Philippe | |
| Author | Franca, Rafael Freitas de Oliveira | |
| Author | Lacerda, Marcus Vinicius Guimarães de | |
| Author | Castilho, Marcia da Costa | |
| Author | Brasil, Patrícia | |
| Author | Sequeira, Patrícia Carvalho de | |
| Author | Mello, Maeve Brito de | |
| Author | Bermudez, Ximena Pamela Diaz | |
| Author | Modjarrad, Kayvon | |
| Author | Meurant, Robyn | |
| Author | Landoulsi, Sihem | |
| Author | Benzaken, Adele Schwartz | |
| Author | Filippis, Ana Maria Bispo de | |
| Author | Broutet, Nathalie Jeanne Nicole | |
| Access date | 2018-08-02T12:19:44Z | |
| Available date | 2018-08-02T12:19:44Z | |
| Document date | 2018 | |
| Citation | CALVET, Guilherme Amaral et al. Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil. BMC Infectious Diseases, v. 18, p. 1-17, 2018. | pt_BR |
| ISSN | 1471-2334 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27783 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Arbovirus | pt_BR |
| Subject in Portuguese | Flavivírus | pt_BR |
| Subject in Portuguese | Zika virus | pt_BR |
| Subject in Portuguese | Fluidos corporais | pt_BR |
| Subject in Portuguese | Persistência | pt_BR |
| Subject in Portuguese | Doenças infecciosas emergentes | pt_BR |
| Subject in Portuguese | Reação em Cadeia da Polimerase em Tempo Real | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1186/s12879-018-2965-4 | |
| Abstract | Background: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission. Methods: This observational cohort study will recruit non-pregnant participants aged 18 years and above with
confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12 months. Discussion: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data
collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and
serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | World Health Organization. Geneva, Switzerland. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de. Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. Brasília. DF, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
| Affilliation | World Health Organization. Geneva, Switzerland. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | World Health Organization. Pan American Health Organization. Department of Communicable Diseases and Health Analysis. Washingto, DC, USA. | pt_BR |
| Affilliation | Universidade de Brasília. Departamento de Saúde Pública. Brasília, DF, Brasil / Organização Mundial de Saúde. Organização Pan Americana de Saúde. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Reed Army Institute of Research. Silver Spring, USA. | pt_BR |
| Affilliation | World Health Organization. Geneva, Switzerland. | pt_BR |
| Affilliation | World Health Organization. Geneva, Switzerland. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de. Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. Brasília. DF, Brasil / Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | World Health Organization. Geneva, Switzerland. | pt_BR |
| Affilliation | ZIKABRA Study Team. | pt_BR |
| Subject | Arbovirus | pt_BR |
| Subject | Flavivirus | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Body fluids | pt_BR |
| Subject | Persistence | pt_BR |
| Subject | Rt-Pcr | pt_BR |
| Subject | Emerging infectious diseases | pt_BR |
| Subject | Brazil | pt_BR |
| DeCS | Reação em Cadeia da Polimerase em Tempo Real | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
