| Author | Bottecchia, Marcelle | |
| Author | Souto, Francisco J. D. | |
| Author | O, Kycia M. R. | |
| Author | Amendola, Marcia | |
| Author | Brandão, Carlos E. | |
| Author | Niel, Christian | |
| Author | Gomes, Selma A. | |
| Access date | 2018-08-02T14:57:58Z | |
| Available date | 2018-08-02T14:57:58Z | |
| Document date | 2008 | |
| Citation | BOTTECCHIA, Marcelle; et al. Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil. BMC Microbiology, v. 8, n.11, 10p, Jan. 2008. | pt_BR |
| ISSN | 1471-2180 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27796 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Genótipos do vírus da Hepatite B | pt_BR |
| Subject in Portuguese | Mutações | pt_BR |
| Subject in Portuguese | Resistência a medicamentos | pt_BR |
| Subject in Portuguese | Terapia com Lamivudina | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1186/1471-2180-8-11 | |
| Abstract | Lamivudine is an oral nucleoside analogue widely used for the treatment of chronic hepatitis B. The main limitation of lamivudine use is the selection of resistant mutations that increases with time of utilization. Hepatitis B virus (HBV) isolates have been classified into eight genotypes (A to H) with distinct geographical distributions. HBV genotypes may also influence pathogenic properties and therapeutic features. Here, we analyzed the HBV genotype distribution and the nature and frequency of lamivudine resistant mutations among 36 patients submitted to lamivudine treatment for 12 to 84 months. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso. Faculdade de Ciências Médicas. Núcleo de Estudos de Doenças Infecciosas e Tropicais. Cuiabá, MT, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil / Fundação Municipal de Saúde de Petrópolis. Hospital Alcides Carneiro. Petrópolis, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Hepatitis B virus genotypes | pt_BR |
| Subject | resistance mutations | pt_BR |
| Subject | lamivudine therapy | pt_BR |
| Subject | Brazil | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
