| Author | Nascimento, Eduardo J. M. | |
| Author | Silva, Ana M. | |
| Author | Cordeiro, Marli T. | |
| Author | Brito, Carlos A. | |
| Author | Gil, Laura H. V. G. | |
| Author | Braga-Neto, Ulisses | |
| Author | Marques, Ernesto T. A. | |
| Access date | 2018-08-03T11:55:04Z | |
| Available date | 2018-08-03T11:55:04Z | |
| Document date | 2009 | |
| Citation | NASCIMENTO, Eduardo J. M. et al. Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity. PloS One, v. 4, n. 8, p. e6782, 26 ago. 2009. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27827 | |
| Sponsorship | Instituto Nacional de Alergia e Doenças Infecciosas (NIAID / NIH) através do Grant U19 AI56541 e do PDTIS RVR09-FIOCRUZ. | pt_BR |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Alternative complement pathway deregulation is correlated with dengue severity | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0006782 | |
| Abstract | The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components in blood samples from dengue fever (DF) and dengue hemorrhagic fever (DHF) patients and found that the level of complement activation is associated with disease severity. | pt_BR |
| Affilliation | The Johns Hopkins School of Medicine. Division of Infectious Diseases. Department of Medicine. Baltimore, Maryland, United States of America. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Texas A&M University. Department of Electrical and Computer Engineering. College Station, Texas, United States of America. | pt_BR |
| Affilliation | The Johns Hopkins School of Medicine. Division of Infectious Diseases. Department of Medicine. Baltimore, Maryland, United States of America / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / The Johns Hopkins School of Medicine. Department of Pharmacology and Molecular Sciences. Baltimore, Maryland, United States of America. | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Ativação Complementar | pt_BR |
| DeCS | Proteínas do Sistema Complementar / metabolismo | pt_BR |
| DeCS | Dengue / metabolismo | pt_BR |
| DeCS | Dengue / fisiopatologia | pt_BR |
| DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
| DeCS | Fêmea | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Meia idade | pt_BR |
| DeCS | Índice de gravidade da doença | pt_BR |
| DeCS | Adulto jovem | pt_BR |
