| Author | Torres, F. D. | |
| Author | Almeida, S. R. | |
| Author | Silva, M. S. | |
| Author | Weiblen, R. | |
| Author | Flores, E. F. | |
| Access date | 2018-08-06T12:02:21Z | |
| Available date | 2018-08-06T12:02:21Z | |
| Document date | 2009 | |
| Citation | TORRES, F. D. et al. Distribution of Latent Bovine Herpesvirus 2 DNA in Tissues of Experimentally Infected Sheep. Research in Veterinary Science, v. 87, n. 1, p. 161–166, ago. 2009. | pt_BR |
| ISSN | 1532-2661 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27851 | |
| Sponsorship | A FD Torres possui assistências do CNPq. EF Flores (101666 / 2004-0) e R. Weiblen (301339 / 2004-0) são bolsistas de pesquisa do CNPq. | pt_BR |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Herpesvirus bovino 2 | pt_BR |
| Subject in Portuguese | BoHV-2 | pt_BR |
| Subject in Portuguese | Infecção latente | pt_BR |
| Subject in Portuguese | Ovelhas | pt_BR |
| Title | Distribution of latent bovine herpesvirus 2 DNA in tissues of experimentally infected sheep | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.rvsc.2008.12.003 | |
| Abstract | The biology of latent infection by bovine herpesvirus 2 (BoHV-2), the agent of mammillitis in cows, remains largely unknown. We herein report attempts to reactivate the latent infection and investigated the sites of BoHV-2 latency in experimentally infected sheep. Ewes inoculated with BoHV-2 in the udder's skin shed virus for up to five days, developed mammillitis and seroconverted. However, attempts to reactivate latent infection by dexamethasone administration at day 40 pi failed. Nevertheless, viral DNA--and not infectious virus--was detected by PCR in several nerve ganglia and/or regional lymph nodes (LNs) of all animals at day 40 post-reactivation. Likewise, lambs previously inoculated with BoHV-2 in the nose harbored latent viral DNA in trigeminal ganglia, tonsils and regional LNs. These results demonstrate that BoHV-2 establishes latent infection in nerve ganglia and in regional lymphoid tissues, yet virus reactivation is not easily achieved by standard protocols used. | pt_BR |
| Affilliation | Universidade Federal de Santa Maria (UFSM). Departamento de Medicina Veterinária Preventiva (DMVP) e de Microbiologia e Parasitologia, DMVP/CCR/UFSM. Santa Maria, RS, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Santa Maria (UFSM). Departamento de Medicina Veterinária Preventiva (DMVP) e de Microbiologia e Parasitologia, DMVP/CCR/UFSM. Santa Maria, RS, Brazil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Santa Maria (UFSM). Departamento de Medicina Veterinária Preventiva (DMVP) e de Microbiologia e Parasitologia, DMVP/CCR/UFSM. Santa Maria, RS, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Santa Maria (UFSM). Departamento de Medicina Veterinária Preventiva (DMVP) e de Microbiologia e Parasitologia, DMVP/CCR/UFSM. Santa Maria, RS, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Santa Maria (UFSM). Departamento de Medicina Veterinária Preventiva (DMVP) e de Microbiologia e Parasitologia, DMVP/CCR/UFSM. Santa Maria, RS, Brazil. | pt_BR |
| Subject | Bovine herpesvirus 2 | pt_BR |
| Subject | BoHV-2 | pt_BR |
| Subject | Latent infection | pt_BR |
| Subject | Sheep | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | DNA Viral / isolamento e purificação | pt_BR |
| DeCS | DNA Viral / metabolismo | pt_BR |
| DeCS | Fêmea | pt_BR |
| DeCS | Herpes simplex / veterinária | pt_BR |
| DeCS | Herpes Simplex / virologia | pt_BR |
| DeCS | Herpesvirus 2, bovino / genética | pt_BR |
| DeCS | Lactação | pt_BR |
| DeCS | Ovelhas | pt_BR |
| DeCS | Doenças dos Ovinos / virologia | pt_BR |
| DeCS | Distribuição de Tecidos | pt_BR |
| DeCS | Latência do vírus | pt_BR |
| DeCS | Derramamento de vírus | pt_BR |
| Embargo date | 2050-01-01 | |
