| Author | Queiroz, Artur Trancoso Lopo de | |
| Author | Santos, Luciane Amorim | |
| Author | Moreau, Domingos Ramon | |
| Author | Oliveira, Tulio de | |
| Author | Watkins, David I | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Access date | 2011-08-08T19:15:22Z | |
| Available date | 2011-08-08T19:15:22Z | |
| Document date | 2007 | |
| Citation | QUEIROZ, A. T. L. de. et al. Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil. The Brazilian Journal of Infectious Diseases, v.11, n.1, p.27-30, 2007. | pt_BR |
| ISSN | 1413-8670 | |
| URI | https://www.arca.fiocruz.br/handle/icict/2790 | |
| Description | Agradecimentos a ATLQ e LAS que contribuíram igualmente para este trabalho, além de Elisabeth Deliège por sua assistência técnica. | pt_BR |
| Sponsorship | Pesquisa parcialmente financiada pela Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e PN-DST/AIDS, Ministério da Saúde, Brasil. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Brazilian Society of Infectious Diseases | pt_BR |
| Rights | open access | en |
| Subject in Portuguese | HIV-1 | pt_BR |
| Subject in Portuguese | Vacina | pt_BR |
| Subject in Portuguese | Epitopo | pt_BR |
| Subject in Portuguese | Genes env | pt_BR |
| Title | Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil | pt_BR |
| Type | Article | pt_BR |
| Abstract | Genetic analysis of HIV-1 is essential to improve treatment strategies and select epitopes for vaccine programs. The
objective of this study was to determine whether known CD4+ and CD8+ epitopes were present in Brazilian HIV-1 strains. We used previously described CD8+ and CD4+ epitopes from the Los Alamos laboratory to search for these epitopes in the Brazilian sequences using the HIVbase program and we compared the frequency results with the analyses using physical-chemical profile tools from Network Protein Sequence Analysis (NPSA), and the SYFPEITHI program. Furthermore, this analysis was carried out with the Prosite tool using the GeneDoc program and ds/dn analyses using the Synonymous Nonsynonymous Analysis Program (SNAP). The HIVbase epitope mapping demonstrated that 30 CD8+ and 6 CD4+ epitopes were present in the Brazilian sequences at a high frequency. Only two of these epitopes were heavily glycosylated. Interestingly, ds/dn analyses showed evidence of purifying selective pressure. These types of analyses could be useful for the assessment of possible vaccine efficiency in populations. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública / Fundação para o Desenvolvimento da Ciência. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | University of Oxford. Department of Zoology. Oxford, United Kingdom | pt_BR |
| Affilliation | University of Wisconsin Medical School. Department of Pathology. Madison, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública / Fundação para o Desenvolvimento da Ciência. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública / Fundação para o Desenvolvimento da Ciência. Salvador, BA, Brasil | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Vaccine | pt_BR |
| Subject | Epitope | pt_BR |
| Subject | env | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Linfócitos T CD4-Positivos | pt_BR |
| DeCS | Linfócitos T CD8-Positivos | pt_BR |
| DeCS | Epitopos | pt_BR |
| DeCS | Produtos do Gene env | pt_BR |
| DeCS | Infecções por HIV | pt_BR |
| DeCS | HIV-1 | pt_BR |
| DeCS | Humanos | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
