Author | Adesse, Daniel | |
Author | Lisanti, Michael P. | |
Author | Spray, David C. | |
Author | Machado, Fabiana S. | |
Author | Meirelles, Maria de Nazareth | |
Author | Tanowitz, Herbert B. | |
Author | Garzoni, Luciana Ribeiro | |
Access date | 2018-08-08T11:59:20Z | |
Available date | 2018-08-08T11:59:20Z | |
Document date | 2010 | |
Citation | ADESSE, Daniel; et al. Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart. Cell Cycle, v.9, n.8, p.1639-1646, Apr. 2010. | pt_BR |
ISSN | 1538-4101 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27996 | |
Language | eng | pt_BR |
Publisher | Taylor & Francis | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Trypanosoma Cruzi | pt_BR |
Subject in Portuguese | Miócitos Cardíacos | pt_BR |
Subject in Portuguese | Cavéolas | pt_BR |
Subject in Portuguese | Caveolinas | pt_BR |
Title | Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart | pt_BR |
Type | Article | pt_BR |
Abstract | Caveolae are motile, membrane-bound compartments that contain a number of molecules that
participate in cell signaling. Caveolins are protein markers of caveolae and function in a variety of
biological processes. Caveolin-3 (Cav-3) is expressed in muscle cells and Cav-3 null mice display
a cardiomyopathic phenotype. Ultrastructural cytochemistry, confocal microscopy and
immunoblotting revealed a reduction in Cav-3 expression and an activation of ERK (extracellularsignal-
regulated kinase) 48 hours after Trypanosoma cruzi infection of cultured cardiac myocytes.
CD-1 mice infected with the Brazil strain of T. cruzi displayed reduced expression of Cav-3 and
activation of ERK 66 days post infection (dpi). By 180 dpi there was a normalization of these
values. These data suggest that the reduction in Cav-3 expression and the activation of ERK
during the early phase of infection may contribute to the pathogenesis of chagasic
cardiomyopathy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Department of Pathology. Bronk, NY, USA / Albert Einstein College of Medicine. Dominik Purpura Department of Neuroscience. Bronx, NY, USA. | pt_BR |
Affilliation | Thomas Jefferson University. Department of Stem Cell Biology & Regenerative Medicine and the Kimmel Cancer Center. Philadelphia, PA, USA / University of Genoa and G. Gaslini Pediatric Institute. The Muscular and Neurodegenerative Disease Unit. Genoa, Italy. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Department of Medicine. Bronx, NY, USA / Albert Einstein College of Medicine. Dominik Purpura Department of Neuroscience. Bronx, NY, USA. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Department of Pathology. Bronk, NY, USA / Albert Einstein College of Medicine. Department of Medicine. Bronx, NY, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Trypanosoma Cruzi | pt_BR |
Subject | cardiac myocytes | pt_BR |
Subject | caveolin-3 | pt_BR |
Subject | caveolae | pt_BR |
Subject | ERK | pt_BR |
e-ISSN | 1551-4005 | |
Embargo date | 2030-01-01 | |