| Author | Carneiro, Valdirene Leão | |
| Author | Bendicho, Maria Teresita | |
| Author | Santos, Rosalina Guedes | |
| Author | Casela, Marilda | |
| Author | Martins Netto, Eduardo | |
| Author | Mota, Scarlet Torres Moraes | |
| Author | Pina, Iza Cristina Araújo | |
| Author | Nascimento, Roberto Meyer | |
| Author | Freire, Songeli Menezes | |
| Author | Barbosa, Theolis Costa | |
| Access date | 2018-08-13T14:23:58Z | |
| Available date | 2018-08-13T14:23:58Z | |
| Document date | 2018 | |
| Citation | CARNEIRO, V. L. et al. Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism. Brazilian Journal of Infectious Diseases, v. 22, n. 3, p. 202–207, 2018. | pt_BR |
| ISSN | 1413-8670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28070 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (INCT-DT/MCT/CNPq 573839/2008-5) and Fundação de Amparo à Pesquisa do Estado da Bahia (PET035/2013). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Infecção por tuberculose | pt_BR |
| Subject in Portuguese | Variação genética | pt_BR |
| Subject in Portuguese | Sensitivitya | pt_BR |
| Title | Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.bjid.2018.04.004 | |
| Abstract | Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG+874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG+874 A/T polymorphism on interferon-gamma test performance. Methods: Patients diagnosed with pulmonary tuberculosis (75), volunteers with positivetuberculin skin test (70) and healthy volunteers with negative tuberculin skin test and no his-tory of contact with tuberculosis (57) were evaluated regarding the IFNG + 874 genotype andthe IFN- levels in whole blood cultures performed using an interferon-gamma commercialkit (QuantiFERON-TB®Gold In-Tube).Results: IFN- production was not influenced by the IFNG + 874 genotype, regardless of anti-gen or mitogen-based stimulation, which suggests that other genes may influence IFN- production in response to mycobacteria. The IFNG + 874 polymorphism was found to exertno influence over QFT-IT test sensitivity in our study. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para a Investigação da Tuberculose. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | Tuberculosis infection | pt_BR |
| Subject | Genetic variation | pt_BR |
| Subject | Sensitivitya | pt_BR |
