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| Autor | Pérez, Ana Rosa | |
| Autor | Bottasso, Oscar | |
| Autor | Savino, Wilson | |
| Fecha de acceso | 2018-08-16T14:03:46Z | |
| Fecha de disponibilización | 2018-08-16T14:03:46Z | |
| Fecha de publicación | 2009 | |
| Referencia | PÉREZ, Ana Rosa; BOTASSO, Oscar; SAVINO, Wilson. The Impact of Infectious Diseases upon Neuroendocrine Circuits. Neuroimmunomodulation, v.16, p.96-105, 2009. | pt_BR |
| ISSN | 1021-7401 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28181 | |
| Idioma | eng | pt_BR |
| Editor | Karger Publishers | pt_BR |
| Derechos de autor | restricted access | |
| Palabras clave en Portugués | Timo | pt_BR |
| Palabras clave en Portugués | Glucocorticoides | pt_BR |
| Palabras clave en Portugués | Hormônios Esteroides Gonadais | pt_BR |
| Palabras clave en Portugués | Citocinas | pt_BR |
| Palabras clave en Portugués | Extracellular matrix | pt_BR |
| Palabras clave en Portugués | Eixo hipotálamo-hipófise-adrenal | pt_BR |
| Palabras clave en Portugués | Infecções por patógenos intracelulares | pt_BR |
| Palabras clave en Portugués | Atrofia do timo | pt_BR |
| Título | The impact of infectious diseases upon neuroendocrine circuits | pt_BR |
| Tipo del documento | Article | |
| DOI | 10.1159/000180264 | |
| Resumen en Inglés | During infectious diseases, neuroendocrine and immune networks act in concert, facilitating host response. It is known that infections cause profound immune changes, but the impact upon immunoendocrine circuits has been less studied. Disorders in the hypothalamic-pituitary-adrenal (HPA) axis were frequently observed associated with infections, and these changes often occur in parallel to alterations in the systemic cytokine network. Explanations for the infection-associated immunoendocrine disturbances include several and not mutually exclusive possibilities. Changes in cytokine levels can enhance or suppress the HPA axis, by acting at the hypothalamus-pituitary unit and/or at the adrenal glands. In situ inflammatory reactions or structural changes like vascular alterations or an enhanced extracellular matrix deposition in the endocrine microenvironment may also lead to a transient HPA dysfunction. Lastly, a microbe-related effect by means of pathogen infiltration or exploitation of the host's hormonal microenvironment may be involved as well. A better understanding of the relevance of immunoendocrine communication during infectious diseases, and how disturbances in the flux of information lead to neuroendocrine immune-related disorders will provide important insights into mechanisms underlying the disease pathology. | pt_BR |
| Afiliación | National University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina. | pt_BR |
| Afiliación | National University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Palavras clave en Inglês | Hypothalamus-pituitary-adrenal axis | pt_BR |
| Palavras clave en Inglês | Intracellular pathogen infections | pt_BR |
| Palavras clave en Inglês | thymus | pt_BR |
| Palavras clave en Inglês | Glucocorticoids | pt_BR |
| Palavras clave en Inglês | Sex hormones | pt_BR |
| Palavras clave en Inglês | Cytokines | pt_BR |
| Palavras clave en Inglês | Extracellular matrix | pt_BR |
| Palavras clave en Inglês | Thymic atrophy | pt_BR |
| e-ISSN | 1423-0216 | |
| Fecha de embargo | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero |
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