| Author | Muñoz, Juan José | |
| Author | García-Ceca, Javier | |
| Author | Alfaro, David | |
| Author | Stimamiglio, Marco Augusto | |
| Author | Cejalvo, Teresa | |
| Author | Jiménez, Eva | |
| Author | Zapata, Agustín G. | |
| Access date | 2018-08-16T15:37:38Z | |
| Available date | 2018-08-16T15:37:38Z | |
| Document date | 2009 | |
| Citation | MUÑOZ, Juan José; et al. Organizing the Thymus Gland The Role of Eph and Ephrins. Neuroimmunomodulation: Ann. N.Y. Acad. Sci., v.1153, p.14–19, 2009. | pt_BR |
| ISSN | 1021-7401 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28188 | |
| Language | eng | pt_BR |
| Publisher | Karger Publishers | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Timócitos | pt_BR |
| Subject in Portuguese | células epiteliais do timo | pt_BR |
| Subject in Portuguese | Efrinas | pt_BR |
| Subject in Portuguese | Receptores da Família Eph | pt_BR |
| Title | Organizing the thymus gland: The role of Eph and Ephrins | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1749-6632.2008.03965.x | |
| Abstract | Eph receptors and their ligands, ephrins, are molecules involved in the morphogenesis of numerous tissues, including the central nervous system in which they play a key role in determining cell positioning and tissue domains containing or excluding nerve fibers. Because common features have been suggested to occur in the microenvironmental organization of brain and thymus, a highly compartmentalized organ central for T cell differentiation, we examined the expression and possible role of Eph/ephrins in the biology of the thymus gland. We reviewed numerous in vivo and in vitro results that confirm a role for Eph and ephrins in the maturation of the thymic epithelial cell (TEC) network and T cell differentiation. Their possible involvement in different steps of early thymus organogenesis, including thymus primordium branching, lymphoid colonization, and thymocyte-TEC interactions, that determine the organization of a mature three-dimensional thymic epithelial network is also analyzed. | pt_BR |
| Affilliation | Complutense University. Faculty of Biology. Depatrment of Cell Biology. Madrid, Spain. | pt_BR |
| Affilliation | Complutense University. Faculty of Biology. Department of Cell Biology. Madrid, Spain. | pt_BR |
| Affilliation | Complutense University. Faculty of Biology. Department of Cell Biology. Madrid, Spain. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Complutense University. Faculty of Biology. Department of Cell Biology. Madrid, Spain. | pt_BR |
| Affilliation | Complutense University. Faculty of Biology. Depatment of Medicine. Madrid, Spain. | pt_BR |
| Affilliation | Complutense University. Faculty of Biology. Depatment of Cell Biology. Madrid, Spain. | pt_BR |
| Subject | thymocytes | pt_BR |
| Subject | thymic epithelial cells | pt_BR |
| Subject | Eph | pt_BR |
| Subject | ephrins | pt_BR |
| e-ISSN | 1423-0216 | |
| Embargo date | 2030-01-01 | |
