| Author | Baptista, Ana Paula | |
| Author | Andrade, Zilton de Araújo | |
| Access date | 2011-08-30T18:52:38Z | |
| Available date | 2011-08-30T18:52:38Z | |
| Document date | 2005 | |
| Citation | BAPTISTA, A. P.; ANDRADE, Z. A. Angiogenesis and schistosomal granuloma formation. Memórias do Instituto Oswaldo Cruz, v.100, n.2, p.183-5, 2005. | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/2821 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Animais | pt_BR |
| Subject in Portuguese | Modelos Animais de Doenças | pt_BR |
| Subject in Portuguese | Feminino | pt_BR |
| Subject in Portuguese | Fibrose | pt_BR |
| Subject in Portuguese | Granuloma | pt_BR |
| Subject in Portuguese | Hepatopatias Parasitárias | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Subject in Portuguese | Neovascularização Patológica | pt_BR |
| Subject in Portuguese | Schistosoma Mansoni | pt_BR |
| Subject in Portuguese | Esquistossomose mansoni | pt_BR |
| Subject in Portuguese | Fatores do Tempo | pt_BR |
| Title | Angiogenesis and schistosomal granuloma formation | pt_BR |
| Type | Article | pt_BR |
| Abstract | An increasing amount of evidences points to angiogenesis as playing a paramount role in fibrosis development.
However, granulomas in general, and periovular schistosomal granulomas in particular, are considered avascular
structures, although they usually result in dense areas of focal fibrosis. In order to clarify this apparent paradox, the
presence of blood vessels was systematically searched in hepatic schistosomal granulomas of mice, during different
stages of the infection, and at different stages of granuloma evolution, by means of vascular injections of colored
masses, demonstration of laminin in vascular basement membranes and by ultra structural analysis. Vascular
proliferation appeared evident at the early stages of granuloma formation, gradually decreasing thereafter, older
granulomas becoming almost avascular structures, sometimes delimited at the periphery by a rich vascular network | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil | |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Periovular Granuloma | pt_BR |
| Subject | Angiogenesis | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
