| Author | Meis, Juliana de | |
| Author | Ferreira, Lidia M. S. | |
| Author | Guillermo, Landi V. C. | |
| Author | Silva, Elisabeth M. | |
| Author | Dosreis, George A. | |
| Author | Lopes, Marcela F. | |
| Access date | 2018-08-21T15:33:05Z | |
| Available date | 2018-08-21T15:33:05Z | |
| Document date | 2008 | |
| Citation | MEIS, Juliana de; et al. Apoptosis differentially regulates mesenteric and subcutaneous lymph node immune responses to Trypanosoma cruzi. European Journal of Immunology, v.38, p.139-146, 2008. | pt_BR |
| ISSN | 0014-2980 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28275 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | linfonodos | pt_BR |
| Subject in Portuguese | Células T | pt_BR |
| Title | Apoptosis differentially regulates mesenteric and subcutaneous lymph node immune responses to Trypanosoma cruzi | pt_BR |
| Type | Article | |
| DOI | 10.1002/eji.200737582 | |
| Abstract | Infection with Trypanosoma cruzi causes expansion of subcutaneous (SLN) and atrophy of mesenteric (MLN) lymph nodes. Here we show that excision of MLN increased parasitemia in T. cruzi-infected mice. We then studied how apoptosis of MLN cells affects immune responses to infection. T cell apoptosis increased in the MLN compared to SLN in T. cruzi-infected mice. Absolute numbers of naïve T cells decreased, and activated T cells failed to accumulate in MLN during infection. In addition, activated T cells from MLN produced less IL-2, IFN-gamma, IL-4, and IL-10 than T cells from SLN. Treatment with IL-4 or with caspase-9 inhibitor increased the recovery of viable T cells in vitro. Treatment with caspase-9 inhibitor also increased the production of cytokines by MLN T cells from infected mice. Moreover, injection of a pan caspase inhibitor prevented MLN atrophy during T. cruzi infection. Caspase-9, but not caspase-8, inhibitor also reduced MLN atrophy and increased the recovery of naïve and activated T cells from MLN. These findings indicate that caspase-mediated apoptosis and defective cytokine production are implicated in MLN atrophy and affect immune responses to T. cruzi infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Caspase-9 | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Lymph nodes | pt_BR |
| Subject | T cells | pt_BR |
| e-ISSN | 1521-4141 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
