| Author | Pescarini, Júlia Moreira | pt_BR |
| Author | Strina, Agostino | pt_BR |
| Author | Nery, Joilda Silva | pt_BR |
| Author | Skalinski, Lacita Menezes | pt_BR |
| Author | Andrade, Kaio Vinicius Freitas de | pt_BR |
| Author | Penna, Maria Lucia Fernandes | pt_BR |
| Author | Brickley, Elizabeth B. | pt_BR |
| Author | Rodrigues, Laura Cunha | pt_BR |
| Author | Barreto, Maurício Lima | pt_BR |
| Author | Penna, Gerson Oliveira | pt_BR |
| Access date | 2018-08-22T14:25:16Z | |
| Available date | 2018-08-22T14:25:16Z | |
| Document date | 2018 | |
| Citation | PESCARINI, Júlia Moreira et al. Socioeconomic risk markers of leprosy in high-burden countries: A systematic review and meta-analysis. PLoS Neglected Tropical Diseases, v. 12 , n. 7, p. 1-20, 2018. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28288 | |
| Description | Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. | pt_BR |
| Sponsorship | Capes/Fiocruz - Plano Brasil Sem Miséria and EBB was supported with funding from the Wellcome Trustand the UK's Department for International Development (205377/Z/16/Z) as well as the European Union's Horizon 2020 research and innovation program under ZikaPLAN grant agreement No. 734584. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Hanseníase | pt_BR |
| Subject in Portuguese | Fatores Socioeconômicos | pt_BR |
| Subject in Portuguese | Políticas de controle | pt_BR |
| Subject in Portuguese | Revisão sistemática | pt_BR |
| Subject in Portuguese | Fatores de risco | pt_BR |
| Title | Socioeconomic risk markers of leprosy in high-burden countries: A systematic review and meta-analysis | en |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0006622 | |
| Abstract | Over 200,000 new cases of leprosy are detected each year, of which approximately 7% are associated with grade-2 disabilities (G2Ds). For achieving leprosy elimination, one of the main challenges will be targeting higher risk groups within endemic communities. Nevertheless, the socioeconomic risk markers of leprosy remain poorly understood. To address this gap we systematically reviewed MEDLINE/PubMed, Embase, LILACS and Web of Science for original articles investigating the social determinants of leprosy in countries with > 1000 cases/year in at least five years between 2006 and 2016. Cohort, case-control, cross-sectional, and ecological studies were eligible for inclusion; qualitative studies, case reports, and reviews were excluded. Out of 1,534 non-duplicate records, 96 full-text articles were reviewed, and 39 met inclusion criteria. 17 were included in random-effects meta-analyses for sex, occupation, food shortage, household contact, crowding, and lack of clean (i.e., treated) water. The majority of studies were conducted in Brazil, India, or Bangladesh while none were undertaken in low-income countries. Descriptive synthesis indicated that increased age, poor sanitary and socioeconomic conditions, lower level of education, and food-insecurity are risk markers for leprosy. Additionally, in pooled estimates, leprosy was associated with being male (RR = 1.33, 95% CI = 1.06-1.67), performing manual labor (RR = 2.15, 95% CI = 0.97-4.74), suffering from food shortage in the past (RR = 1.39, 95% CI = 1.05-1.85), being a household contact of a leprosy patient (RR = 3.40, 95% CI = 2.24-5.18), and living in a crowded household (≥5 per household) (RR = 1.38, 95% CI = 1.14-1.67). Lack of clean water did not appear to be a risk marker of leprosy (RR = 0.94, 95% CI = 0.65-1.35). Additionally, ecological studies provided evidence that lower inequality, better human development, increased healthcare coverage, and cash transfer programs are linked with lower leprosy risks. These findings point to a consistent relationship between leprosy and unfavorable economic circumstances and, thereby, underscore the pressing need of leprosy control policies to target socially vulnerable groups in high-burden countries. | en |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / London School of Hygiene & Tropical. Department of Infectious Disease Epidemiology Medicine. London, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal do Vale do São Francisco. Paulo Afonso, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Estadual de Santa Cruz. Ilheus, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Saúde da Comunidade. Niteroi, RJ, Brasil | pt_BR |
| Affilliation | London School of Hygiene & Tropical. Department of Infectious Disease Epidemiology Medicine. London, United Kingdom. | pt_BR |
| Affilliation | London School of Hygiene & Tropical. Department of Infectious Disease Epidemiology Medicine. London, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade de Brasilia. Centro de Medicina Tropical. Brasilia, DF, Brasil. | pt_BR |
| Subject | Leprosy | en |
| Subject | Socioeconomic factors | en |
| Subject | Control policies | en |
| Subject | Systematic review | en |
| Subject | Risk Factors | en |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
