| Author | Zanini, Graziela Maria | |
| Author | Carvalho, Leonardo Jose de Moura | |
| Author | Brahimi, Karima | |
| Author | Passos, Luiz Fernando | |
| Author | Guimarães, Swami Jose de Souza | |
| Author | Machado, Eduardo da Silva | |
| Author | Bianco Junior, Cesare | |
| Author | Riccio, Evelyn Kety Pratt | |
| Author | Sousa, Maria Auxiliadora de | |
| Author | Alecrim, Maria das Gracas Costa | |
| Author | Leite, Nocy | |
| Author | Druilhe, Pierre | |
| Author | Daniel-Ribeiro, Cláudio Tadeu | |
| Access date | 2018-08-23T11:39:28Z | |
| Available date | 2018-08-23T11:39:28Z | |
| Document date | 2009 | |
| Citation | ZANINI, Graziela Maria et al. Sera of patients with systemic lupus erythematosus react with plasmodial antigens and can inhibit the in vitro growth of Plasmodium falciparum. Autoimunity, v. 42, n. 6, p. 545-553, 2009. | pt_BR |
| ISSN | 0891-6934 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28299 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Proteção imunológica | pt_BR |
| Title | Sera of patients with systemic lupus erythematosus react with plasmodial antigens and can inhibit the in vitro growth of Plasmodium falciparum | pt_BR |
| Type | Article | |
| DOI | 10.1080/08916930903039810 | pt_BR |
| Abstract | The acquisition of protective immunity in malaria is a slow process during which autoantibodies are produced. The present work aimed at studying a possible interference of autoimmune responses on malaria immune protection. This was done by investigating the presence of autoantibodies in the sera of malarious patients, by searching for reactivity of autoantibodies from autoimmune patients against plasmodial antigens, and by studying the effect of such antibodies on the in vitro growth of Plasmodium falciparum. Sera from systemic lupus erythematosus (SLE) and malaria patients were tested against autologous and plasmodial antigens. Out of the 109 SLE sera tested, 48 (44%) reacted against the parasite. In addition, 26 (47%) out of 55 randomly selected sera, mainly those containing anti-DNA and antinuclear autoantibodies, were able to inhibit parasite growth to some extent. Conversely, a high frequency (81%) of sera of malaria patients exhibited reactivity against autoantigens. The results show that patients with autoimmune processes can produce antibodies that recognize plasmodial antigens in the absence of plasmodial infection, that malaria patients can produce autoantibodies, that SLE sera can inhibit plasmodial growth in vitro, and that the presence of anti-DNA and antinuclear antibodies may be important in such anti-plasmodial activity. It is concluded that autoimmune responses may have influence on the protective immunity against malaria. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institut Pasteur. Laboratoire de Parasitologie Biomédicale. Paris, France. | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Serviço de Reumatologia. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Hospital de Servidores do Estado do Rio de Janeiro. Serviço de Reumatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Coleção de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Serviço de Reumatologia. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Institut Pasteur. Laboratoire de Parasitologie Biomédicale. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Systemic Lupus Erythematosus | pt_BR |
| Subject | Autoimmune diseases | pt_BR |
| Subject | Autoantibodies | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Immune protection | pt_BR |
| DeCS | Lúpus Eritematoso Sistêmico | pt_BR |
| DeCS | Doenças Autoimunes | pt_BR |
| DeCS | Autoanticorpos | pt_BR |
| DeCS | Malária | pt_BR |
| Embargo date | 2030-01-01 | |
