| Author | Santos, Damião Carlos Moraes dos | |
| Author | Martinho, José Manoel da Silva Gomes | |
| Author | Moreira, Lúcio Filgueiras Pacheco | |
| Author | Araújo, Cristina Carvalho Viana de | |
| Author | Bottino, Adriana Caroli | |
| Author | Pannain, Vera Lúcia | |
| Author | Trinta, Karen Soares | |
| Author | Gandini, Mariana | |
| Author | Neves, Patrícia Cristina da Costa | |
| Author | Matos, Denise Cristina de Souza | |
| Author | Caputo, Luzia Fátima Gonçalves | |
| Author | Pelajo-Machado, Marcelo | |
| Author | Pinto, Marcelo Alves | |
| Access date | 2018-08-27T11:52:37Z | |
| Available date | 2018-08-27T11:52:37Z | |
| Document date | 2009 | |
| Citation | SANTOS, Damião Carlos Moraes dos et al. Eosinophils involved in fulminant hepatic failure are associated with high interleukin-6 expression and absence of interleukin-5 in liver and peripheral blood. Liver International, v. 29, n. 4, p. 544-551, Apr. 2009. | pt_BR |
| ISSN | 1478-3223 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28364 | |
| Language | eng | en_US |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Proteína-1a inflamatória de macrófagos | pt_BR |
| Title | Eosinophils involved in fulminant hepatic failure are associated with high interleukin-6 expression and absence of interleukin-5 in liver and peripheral blood | en_US |
| Type | Article | |
| DOI | 10.1111/j.1478-3231.2008.01872.x | |
| Abstract | Background/Aims: Although eosinophils are considered to play an important role in the pathogenesis of various parasitic, allergic and autoimmune digestive diseases, their role in fulminant hepatic failure (FHF) is unknown. Our contribution was to identify and quantify eosinophils and cytokine levels [interleukin (IL)-6, IL-5 and macrophage inflammatory protein (MIP)-1a] in liver parenchyma and peripheral blood from FHF patients at pre- and post-transplantation steps. Methods: Histochemical methods were used to identify/quantify eosinophils in liver samples. Liver and plasma cytokine levels were quantified using immunofluorescence methods. Results: Fulminant hepatic failure patients showed a high number of intrahepatic eosinophils concomitant with an increased expression of IL-6, besides the IL-6-positive eosinophils associated with the lack of IL-5. Also, an increased number of eosinophils and soluble IL-6 and MIP-1a with a low expression of IL-5 in peripheral blood at the pretransplantation step was observed. Conclusions: The increased number of intrahepatic eosinophils, besides the high production of IL-6, may be involved in liver dysfunction. In addition, the low presence of IL-5 in liver and peripheral blood may represent a particular pattern of eosinophil behaviour in human liver failure, which may also involve MIP-1a. Further ex vivo studies are necessary to evaluate the specific role of eosinophils in FHF. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Hospital Geral de Bonsucesso. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Geral de Bonsucesso. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Geral de Bonsucesso. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Eosinophils | en_US |
| Subject | Fulminant hepatic failure | en_US |
| Subject | Interleukin-5 | en_US |
| Subject | Interleukin-6 | en_US |
| Subject | Macrophage inflammatory protein-1a | en_US |
| DeCS | Falência Hepática Aguda | pt_BR |
| DeCS | Eosinófilos | pt_BR |
| DeCS | Interleucina-5 | pt_BR |
| DeCS | Interleucina-6 | pt_BR |
| e-ISSN | 1478-3231 | pt_BR |
| Embargo date | 2030-01-01 | pt_BR |
