| Author | Coutinho, Diego de Sá | |
| Author | Pacheco, Maria Talita | |
| Author | Frozza, Rudimar Luiz | |
| Author | Bernardi, Andressa | |
| Access date | 2018-08-30T12:34:44Z | |
| Available date | 2018-08-30T12:34:44Z | |
| Document date | 2018 | |
| Citation | COUTINHO, Diego de Sá; et al. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. International Journal of Molecular Sciences, v.19, n.1812, 25p, 2018. | pt_BR |
| ISSN | 1661-6596 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28463 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doenças crônicas | pt_BR |
| Subject in Portuguese | Inflamacão | pt_BR |
| Title | Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights | pt_BR |
| Type | Article | |
| DOI | 10.3390/ijms19061812 | |
| Abstract | Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | resveratrol | pt_BR |
| Subject | chronic diseases | pt_BR |
| e-ISSN | 1422-0067 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
