| Author | Valente, Richard Hemmi | |
| Author | Luna, Milene Schmidt | |
| Author | Oliveira, Ursula Castro de | |
| Author | Nishiyama Junior, Milton Yutaka | |
| Author | Azevedo, Inácio de Loiola Junqueira de | |
| Author | Portes Junior, José Antonio | |
| Author | Clissa, Patricia Bianca | |
| Author | Viana, Luciana Godoy | |
| Author | Sanches, Leonardo | |
| Author | Silva, Ana Maria Moura da | |
| Author | Perales, Jonas | |
| Author | Yamanouye, Norma | |
| Access date | 2018-08-30T15:55:10Z | |
| Available date | 2018-08-30T15:55:10Z | |
| Document date | 2018 | |
| Citation | VALENTE, Richard Hemmi; et al. Bothrops jararaca accessory venom gland is an ancillary source of toxins to the snake. Journal of Proteomics, v.177, n.137–147, Jan. 2018. | pt_BR |
| ISSN | 1874-3919 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28475 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Serpentes | pt_BR |
| Subject in Portuguese | Toxinas | pt_BR |
| Subject in Portuguese | Bothrops | pt_BR |
| Subject in Portuguese | Glândula acessória | pt_BR |
| Subject in Portuguese | Transcriptômica | pt_BR |
| Subject in Portuguese | Proteômica | pt_BR |
| Title | Bothrops jararaca accessory venom gland is an ancillary source of toxins to the snake | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jprot.2017.12.009 | |
| Abstract | In Viperidae snakes, it has been attributed to the main venom gland, a component of the venom gland apparatus, the function of synthesizing all venom toxins and storing them inside a basal-central lumen. However, the role of the accessory gland is still unknown. Here, we analyzed the proteome and the transcriptome of the accessory gland during venom production and secretion cycle. We showed that the accessory gland expresses and synthesizes toxins that are similar to those produced by the main venom gland such as C-type lectin/C-type lectin-like proteins, metalloproteinase, phospholipase A2, cysteine rich secretory protein, nerve growth factor, vascular endothelial growth factor, serine proteinase, and l-amino acid oxidase. Our data have shown that toxin synthesis in the accessory gland is asynchronous when compared to the same process in the venom gland. Moreover, this gland also expresses inhibitors of venom phospholipases A2 and metalloproteinases. Transcriptome analysis showed that the transcripts that correspond to toxins in the accessory gland have a good correlation to the main venom gland transcripts. Therefore, it is proposed that the accessory gland is an ancillary source of toxins to the snake, and provides inhibitors that could control venom toxicity (and integrity) during storage. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas. Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Farmacologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório Especial de Toxinologia Aplicada. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório Especial de Toxinologia Aplicada. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório Especial de Toxinologia Aplicada. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Farmacologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Ecologia e Evolução. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil / Instituto Butantan. Laboratório de Ecologia e Evolução. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas. Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Farmacologia. São Paulo, SP, Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas. Brasil. | pt_BR |
| Subject | Accessory gland | pt_BR |
| Subject | Proteomics | pt_BR |
| Subject | Transcriptomics | pt_BR |
| Subject | Toxins | pt_BR |
| Subject | Bothrops jararaca | pt_BR |
| Subject | Snake | pt_BR |
| e-ISSN | 1876-7737 | |
| Embargo date | 2030-01-01 | |
