| Author | Couto, Janaína A. | |
| Author | Saraiva, Karina L. A. | |
| Author | Barros, Cleiton D. | |
| Author | Udrisar, Daniel P. | |
| Author | Peixoto, Christina A. | |
| Author | Vieira, Juliany S. B. César | |
| Author | Lima, Maria C. | |
| Author | Galdino, Suely L. | |
| Author | Pitta, Ivan R. | |
| Author | Wanderley, Maria I. | |
| Access date | 2018-08-31T12:07:18Z | |
| Available date | 2018-08-31T12:07:18Z | |
| Document date | 2010 | |
| Citation | COUTO, J. A. et al. Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. Reproductive biology and endocrinology: RB&E, v. 8, p. 13, 9 fev. 2010. | pt_BR |
| ISSN | 1477-7827 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28488 | |
| Sponsorship | Universidade Federal de Pernambuco (UFPE), Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | pt_BR |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Testosterona | pt_BR |
| Subject in Portuguese | Rosiglitazona | pt_BR |
| Subject in Portuguese | Pioglitazona | pt_BR |
| Subject in Portuguese | Célula de Leydig | pt_BR |
| Subject in Portuguese | Pregnenolona | pt_BR |
| Title | Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/1477-7827-8-13 | |
| Abstract | The present study was designed to examine the effect of chronic treatment with rosiglitazone - thiazolidinedione used in the treatment of type 2 diabetes mellitus for its insulin sensitizing effects - on the Leydig cell steroidogenic capacity and expression of the steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme (P450scc) in normal adult rats. | pt_BR |
| Affilliation | Universidade Federal Rural de Pernambuco. Department of Morphology and Physiology. Recife, PE, Brazil. | pt_BR |
| Affilliation | Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil. | pt_BR |
| Affilliation | Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil. | pt_BR |
| Subject | Testosterone | pt_BR |
| Subject | Rosiglitazone | pt_BR |
| Subject | Pioglitazone | pt_BR |
| Subject | Leydig Cell | pt_BR |
| Subject | Pregnenolone | pt_BR |
| DeCS | Células de Leydig / efeitos de drogas | pt_BR |
| DeCS | Esteróides / biossíntese | pt_BR |
| DeCS | Tiazolidinedionas / farmacologia | pt_BR |
| DeCS | Peso Corporal / efeitos de drogas | pt_BR |
| DeCS | Tamanho do órgão / efeitos de drogas | pt_BR |
| DeCS | Fosfoproteínas / metabolismo | pt_BR |
| DeCS | Avaliação de Medicamentos Pré-Clínicos | pt_BR |
| DeCS | Hipoglicemiantes / efeitos adversos | pt_BR |
