| Author | Alvarenga, Daniele Luísa Ribeiro | |
| Author | Silva, Amanda Helen dos Santos | |
| Author | Fiuza, Jacqueline Araújo | |
| Author | Jangola, Soraya Torres Gaze | |
| Author | Oliveira, Jaquelline Germano de | |
| Author | Oliveira, Rodrigo Corrêa | |
| Author | Silva, Carlos Eduardo Calzavara | |
| Author | Xavier, Marcelo Antônio Pascoal | |
| Author | Alves, Érica Alessandra Rocha | |
| Access date | 2018-08-31T17:53:59Z | |
| Available date | 2018-08-31T17:53:59Z | |
| Document date | 2018 | |
| Citation | ALVARENGA, Daniele Luísa Ribeiro et al. HIV aspartyl protease inhibitors modify the percentage of activated leukocytes, as well as serum levels of IL-17A and NO during experimental leishmaniasis. International Immunopharmacology, v. 60, p. 179-188 | pt_BR |
| ISSN | 1567-5769 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28507 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Science | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Leishmania | pt_BR |
| Subject in Portuguese | Lopinavir | pt_BR |
| Subject in Portuguese | Atazanavir | pt_BR |
| Subject in Portuguese | linfocitos | pt_BR |
| Subject in Portuguese | oxido nitrico | pt_BR |
| Subject in Portuguese | citocinas | pt_BR |
| Title | HIV aspartyl protease inhibitors modify the percentage of activated leukocytes, as well as serum levels of IL-17A and NO during experimental leishmaniasis | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.intimp.2018.04.044 | |
| Abstract | HIV aspartyl protease inhibitors are able to modulate multiple defense mechanisms. However, their influence on the immune response against Leishmania has rarely been investigated. The aim of our study was to investigate whether in vivo treatment with HIV aspartyl protease inhibitors is able to modulate the immune response during Leishmania infection. Using Leishmania (L.) amazonensis-infected mice, we analyzed the disease evolution and parasite load, immunophenotypic profiles of splenic T and B lymphocytes, numbers of lymphoid aggregates in the spleen, percentages of circulating atypical lymphocytes and reactive monocytes, and serum levels of cytokines and nitric oxide (NO) after 30 days of oral treatment with lopinavir/ritonavir (LPV/RTV) or atazanavir (ATV). We observed that LPV/RTV and ATV did not modify the disease evolution or parasite load. However, the antiretroviral treatment induced an increase in activated lymphocytes in the spleen and blood, as well as a decrease in CD69 expression in T and B lymphocytes in the spleen. The treatment also resulted in an increase in activated monocytes in the blood. In addition, antiretrovirals decreased levels of IL-17A and increased levels of NO in sera from Leishmania-infected mice. Thus, our results demonstrate for the first time that in vivo treatment with HIV aspartyl protease inhibitors modifies innate and adaptative immune responses during Leishmania infection and suggest that these drugs could change the clinical course of leishmaniasis in HIV infected-individuals. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Patologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Leishmania | pt_BR |
| Subject | Lopinavir | pt_BR |
| Subject | Atazanavir | pt_BR |
| Subject | Lymphocytes | pt_BR |
| Subject | Nitric Oxide | pt_BR |
| Subject | Cytokines | pt_BR |
| Embargo date | 2025-01-01 | |
