| Author | Torres, Dilênia de Oliveira Cipriano | |
| Author | Santos, Ana Célia Oliveira Dos | |
| Author | Silva, Amanda Karolina Soares e | |
| Author | Moura, Patrícia Muniz Mendes Freire de | |
| Author | Beltrão, Eduardo Isidoro Carneiro | |
| Author | Peixoto, Christina Alves | |
| Access date | 2018-09-06T12:14:41Z | |
| Available date | 2018-09-06T12:14:41Z | |
| Document date | 2012 | |
| Citation | TORRES, Dilênia de Oliveira Cipriano et al. Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice. International Journal of Clinical and Experimental Medicine, v. 5, n. 1, p. 56–63, 2012. | pt_BR |
| ISSN | 1940-5901 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28577 | |
| Sponsorship | Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e Fundação de Apoio ao Desenvolvimento Científico de Pernambuco (FACEPE). | pt_BR |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Nutrição materna | pt_BR |
| Subject in Portuguese | Hipercolesterolemia materna | pt_BR |
| Subject in Portuguese | Ômega-6 | pt_BR |
| Subject in Portuguese | Ômega-9 | pt_BR |
| Subject in Portuguese | Prole | pt_BR |
| Subject in Portuguese | MCP-1 | pt_BR |
| Subject in Portuguese | VCAM-1 | pt_BR |
| Subject in Portuguese | Aterogênese | pt_BR |
| Subject in Portuguese | Lipídios sangüíneos | pt_BR |
| Title | Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice | pt_BR |
| Type | Article | pt_BR |
| Abstract | AIMS:
The present study investigated the effect of a maternal diet rich in omega-6 (E6D) or omega-9 (E9D) on atherogenesis in the offspring of mice.
MAIN METHODS:
LDL receptor-deficient mice were fed a diet rich in either omega-6 (E6D) or omega-9 (E9D) for 45 days prior to mating and until the birth of the offspring, evaluating the effect on the offspring aorta in comparison to a standard diet (STD), by immunohistochemical analysis, morphometric analysis and electron microscopy.
KEY FINDINGS:
Hypercholesterolemic female mice fed E6D generated offspring with high levels of total cholesterol, triglycerides (TG) and CC-chemokine ligand 2/monocyte chemoattractant protein 1 (CCL2/ MCP-1) as well as a reduction in high-density lipoprotein. The ascending aorta of these animals exhibited an increase in arterial wall thickness as well as increased expression of CCL2/MCP-1 and vascular cell adhesion molecule 1. The ultrastructural analysis revealed severe alterations in endothelial cells. The offspring from mothers fed E9D exhibited a reduction in TG and an increase in low-density lipoprotein. The ultrastructural analysis revealed a well-preserved aortic endothelium in these animals.
SIGNIFICANCE:
The results suggest that hypercholesterolemic mothers feed a diet rich in omega-6 predispose their offspring to endothelial dysfunction. | pt_BR |
| Affilliation | Universidade de Pernambuco. Hospital Universitário Oswaldo Cruz–HUOC. Pronto-Socorro Cardiológico Universitário de Pernambuco - PROCAPE. Laboratório de Análises Clínicas. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Centro de Tecnologias Estratégicas do Nordeste - CETENE. Recife, PE, Brasil. | pt_BR |
| Subject | Maternal nutrition | pt_BR |
| Subject | Maternal hypercholesterolemia | pt_BR |
| Subject | Omega-6 | pt_BR |
| Subject | Omega-9 | pt_BR |
| Subject | Offspring | pt_BR |
| Subject | MCP-1 | pt_BR |
| Subject | VCAM-1 | pt_BR |
| Subject | Atherogenesis | pt_BR |
| Subject | Blood lipids | pt_BR |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
