| Author | Carvalho, Vinicius F. | |
| Author | Barreto, Emiliano O. | |
| Author | Arantes, Ana Carolina S. | |
| Author | Serra, Magda F. | |
| Author | Ferreira, Tatiana Paula T. | |
| Author | Jannini-Sá, Yago A. P. | |
| Author | Hogaboam, Cory M. | |
| Author | Martins, Marco A. | |
| Author | Silva, Patrícia M. R. | |
| Access date | 2018-09-13T11:41:59Z | |
| Available date | 2018-09-13T11:41:59Z | |
| Document date | 2018 | |
| Citation | CARVALHO, Vinicius F. et al. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators of Inflammation, Volume 2018, Article ID 6150843, 11p, 2018. | pt_BR |
| ISSN | 0962-9351 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28718 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Diabetes | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Vias aéreas | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Title | Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice | pt_BR |
| Type | Article | |
| DOI | 10.1155/2018/6150843 | |
| Abstract | Previous studies described that allergic diseases, including asthma, occur less often than expected in patients with type 1 diabetes. Here, we investigated the influence of diabetes on allergic airway inflammation in a model of experimental asthma in mice. Diabetes was induced by intravenous injection of alloxan into 12 h-fasted A/J mice, followed by subcutaneous sensitization with ovalbumin (OVA) and aluminum hydroxide (Al(OH)3), on days 5 and 19 after diabetes induction. Animals were intranasally challenged with OVA (25 μg), from day 24 to day 26. Alloxan-induced diabetes significantly attenuated airway inflammation as attested by the lower number of total leukocytes in the bronchoalveolar lavage fluid, mainly neutrophils and eosinophils. Suppression of eosinophil infiltration in the peribronchiolar space and generation of eosinophilotactic mediators, such as CCL-11/eotaxin, CCL-3/MIP-1α, and IL-5, were noted in the lungs of diabetic sensitized mice. In parallel, reduction of airway hyperreactivity (AHR) to methacholine, mucus production, and serum IgE levels was also noted under diabetic conditions. Our findings show that alloxan diabetes caused attenuation of lung allergic inflammatory response in A/J mice, by a mechanism possibly associated with downregulation of IgE antibody production. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Cedars-Sinai Medical Center. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Diabetes | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Airway | pt_BR |
| Subject | Mice | pt_BR |
| e-ISSN | 1466-1861 | |
