| Author | Panzenhagen, Pedro Henrique N. | |
| Author | Paul, Narayan C. | |
| Author | Conte, Carlos A. | |
| Author | Costa, Renata G. | |
| Author | Rodrigues, Dália P. | |
| Author | Shah, Devendra H. | |
| Access date | 2018-09-13T16:11:43Z | |
| Available date | 2018-09-13T16:11:43Z | |
| Document date | 2018 | |
| Citation | PANZENHAGEN, Pedro Henrique N. et al. Genetically distinct lineages of Salmonella Typhimurium ST313 and ST19 are present in Brazil. International Journal of Medical Microbiology, v. 308, p.306–316, 2018. | pt_BR |
| ISSN | 1438-4221 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28746 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Salmonella Typhimurium | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Genetically distinct lineages of Salmonella Typhimurium ST313 and ST19 are present in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ijmm.2018.01.005 | |
| Abstract | In sub-Saharan Africa, two genetically distinct lineages of multi-drug resistant non-typhoidal Salmonella (NTS) serovar Typhimurium sequence type 313 (ST313) are known to cause invasive disease among people. S. Typhimurium ST313 has evolved to become more human-adapted and is commonly isolated from systemic sites (eg., blood) from febrile patients in sub-Saharan Africa. Epidemiological studies indicate that S. Typhimurium is frequently isolated from systemic sites from human patients in Brazil, however, it is currently unknown if this pathogen has also evolved to become more invasive and human-adapted in this country. Here we determined genotypic and phenotypic divergence among clinical S. Typhimurium strains isolated from systemic and non-systemic sites from human patients in Brazil. We report that a subset (8/38, 20%) of epidemiologically diverse human clinical strains of S. Typhimurium recovered from systemic sites in Brazil show significantly higher intra-macrophage survival, indicating that this subset is likely more invasive. Using the whole genome sequencing and phylogenetic approaches, we identified S. Typhimurium ST313-lineage in Brazil that is genetically and phenotypically distinct from the known African ST313-lineages. We also report the identification of S. Typhimurium ST19-lineage in Brazil that is evolving similar to ST313 lineages from Africa but is genetically and phenotypically distinct from ST19-lineage commonly associated with the gastrointestinal disease worldwide. The identification of new S. Typhimurium ST313 and ST19 lineages responsible for human illnesses in Brazil warrants further epidemiological investigations to determine the incidence and spread of a genetically divergent population of this important human pathogen. | pt_BR |
| Affilliation | Washington State University. Department of Veterinary Microbiology and Pathology.Pullman, WA, USA / Universidade Federal do Rio de Janeiro. Instituto de Química. Programa de Ciência de Alimentos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Washington State University. Department of Veterinary Microbiology and Pathology.Pullman, WA, USA. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Química. Programa de Ciência de Alimentos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Qualidade em Saúde.Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina Veterinária. Departamento de Tecnologia de Alimentos. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Washington State University. Department of Veterinary Microbiology and Pathology.Pullman, WA, USA. | pt_BR |
| Subject | Salmonella Typhimurium | pt_BR |
| Subject | ST313 | pt_BR |
| Subject | ST19 | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1618-0607 | |
| Embargo date | 2030-01-01 | |
