| Author | Pinheiro, Roberta Olmo | |
| Author | Schmitz, Veronica | |
| Author | Silva, Bruno Jorge de Andrade | |
| Author | Dias, André Alves | |
| Author | Souza, Beatriz Junqueira de | |
| Author | Barbosa, Mayara Garcia de Mattos | |
| Author | Esquenazi, Danuza de Almeida | |
| Author | Pessolani, Maria Cristina Vidal | |
| Author | Sarno, Euzenir Nunes | |
| Access date | 2018-09-18T11:25:33Z | |
| Available date | 2018-09-18T11:25:33Z | |
| Document date | 2018 | |
| Citation | PINHEIRO, Roberta Olmo et al. Innate imune responses in Leprosy. Frontiers in Immunology. v. 9, p. 1-15, Mar. 2018. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28841 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hanseníase | pt_BR |
| Subject in Portuguese | Pele | pt_BR |
| Subject in Portuguese | Mycobacterium leprae | pt_BR |
| Title | Innate Immune Responses in Leprosy | pt_BR |
| Type | Article | |
| DOI | 10.3389/fimmu.2018.00518 | |
| Abstract | Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease. Macrophages, dendritic cells, neutrophils, and keratinocytes are the major cell populations studied and the comprehension of the complex networking created by cytokine release, lipid and iron metabolism, as well as antimicrobial effector pathways might provide data that will help in the development of new strategies for leprosy management. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leprosy | pt_BR |
| Subject | Innate immune responses | pt_BR |
| Subject | Skin | pt_BR |
| Subject | Mycobacterium leprae | pt_BR |
| Subject | Autophagy | pt_BR |
| Subject | Toll-like receptors | pt_BR |
| Subject | Inflammasomes | pt_BR |
| DeCS | Imunidade Inata | pt_BR |
| DeCS | Autofagia | pt_BR |
| DeCS | Receptores Toll-Like | pt_BR |
| DeCS | Inflamassomos | pt_BR |
