| Author | Raboni, Sonia Mara | |
| Author | Stella, Vanessa | |
| Author | Cruz, Cristina R. | |
| Author | França, João B. | |
| Author | Moreira, Suzana | |
| Author | Gonçalves, Lili | |
| Author | Nogueira, Meri B. | |
| Author | Vidal, Luine R. | |
| Author | Almeida, Sergio M. | |
| Author | Debur, Maria C. | |
| Author | Carraro, Hipolito | |
| Author | Santos, Claudia Nunes Duarte dos | |
| Access date | 2018-09-19T19:09:03Z | |
| Available date | 2018-09-19T19:09:03Z | |
| Document date | 2011 | |
| Citation | RABONI, Sonia M. et al. Laboratory Diagnosis, Epidemiology, and Clinical Outcomes of Pandemic Influenza A and Community Respiratory Viral Infections in Southern Brazil. Journal of Clinical Microbiology, v. 49, n. 4, p. 1287–1293, 2011. | pt_BR |
| ISSN | 0095-1137 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28918 | |
| Language | por | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | H1N1 | pt_BR |
| Title | Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1128/JCM.02205-10 | |
| Abstract | Community respiratory viruses (CRVs) are commonly associated with seasonal infections. They have been associated with higher morbidity and mortality among children, elderly individuals, and immunosuppressed patients. In April 2009, the circulation of a new influenza A virus (FLUA H1N1v) was responsible for the first influenza pandemic of this century. We report the clinical and epidemiological profiles of inpatients infected with CRVs or with FLUA H1N1v at a tertiary care hospital in southern Brazil. In addition, we used these profiles to evaluate survivor and nonsurvivor patients infected with FLUA H1N1v. Multiplex reverse transcription-PCR (RT-PCR) and real time RT-PCR were used to detect viruses in inpatients with respiratory infections. Record data from all patients were reviewed. A total of 171 patients were examined over a period of 16 weeks. Of these, 39% were positive for FLUA H1N1v, 36% were positive for CRVs, and 25% were negative. For the FLUA H1N1v- and CRV-infected patients, epidemiological data regarding median age (30 and 1.5 years), myalgia (44% and 13%), need for mechanical ventilation (44% and 9%), and mortality (35% and 9%) were statistically different. In a multivariate analysis comparing survivor and nonsurvivor patients infected with influenza A virus H1N1, median age and creatine phosphokinase levels were significantly associated with a severe outcome. Seasonal respiratory infections are a continuing concern. Our results highlight the importance of studies on the prevalence and severity of these infections and that investments in programs of clinical and laboratory monitoring are essential to detect the appearance of new infective agents. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Pediatria. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Serviço de Epidemiologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Serviço de Epidemiologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Secretaria Estadual de Saúde do Paraná. Laboratório de Saúde Pública. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Unidade de Terapia Intensiva. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Subject | Influenza A Virus | pt_BR |
| Subject | Epidemics | pt_BR |
| Subject | Multiplex Polymerase Chain Reaction | pt_BR |
| Subject | Multivariate Analysis | pt_BR |
| Subject | Virus Diseases | pt_BR |
| Subject in Spanish | Subtipo H1N1 del Virus de la Influenza A | pt_BR |
| Subject in Spanish | Reacción en Cadena de la Polimerasa Multiplex | pt_BR |
| Subject in Spanish | Análisis Multivariante | pt_BR |
| Subject in Spanish | Virosis | pt_BR |
| DeCS | Vírus da Influenza A Subtipo H1N1 | pt_BR |
| DeCS | Epidemias | pt_BR |
| DeCS | Reação em Cadeia da Polimerase Multiplex | pt_BR |
| DeCS | Análise Multivariada | pt_BR |
| DeCS | Viroses | pt_BR |
| e-ISSN | 1098-660X | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
