Author | Esquenazi, Danuza | |
Author | Moreira, A. L. | |
Author | Miranda, A. | |
Author | Nery, J. A. C. | |
Author | Alvarenga, F. F. | |
Author | Sarno, Euzenir Nunes | |
Author | Pereira, G. M. B. | |
Access date | 2018-09-20T17:20:29Z | |
Available date | 2018-09-20T17:20:29Z | |
Document date | 2008 | |
Citation | ESQUENAZI, Danuza; et al. Clinical, immunological and histological aspects of an uncommon type II reaction in patients with lepromatous leprosy. Clinical and Experimental Dermatology, v.33, p.294-297, 2008. | pt_BR |
ISSN | 0307-6938 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28952 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Hanseníase Virchowiana | pt_BR |
Subject in Portuguese | Aspectos clínicos | pt_BR |
Subject in Portuguese | Aspectos imunológicos | pt_BR |
Subject in Portuguese | Aspectos histológicos | pt_BR |
Subject in Portuguese | reação tipo 2 | pt_BR |
Title | Clinical, immunological and histological aspects of an uncommon type II reaction in patients with lepromatous leprosy | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1365-2230.2007.02654.x | |
Abstract | This study reports three cases of an unusual leprotic reaction characterized by superficial bullous ulcerative cutaneous lesions associated with high fever, malaise and oedema in patients with leprosy. Two patients responded to thalidomide treatment, with regression of the symptoms and skin ulcers. The third patient responded to thalidomide plus prednisone. Analysis of the ulcerated skin lesions showed dermal oedema with mononuclear cell infiltrate enriched for gammadelta-positive T lymphocytes and an increased number of Mycobaterium leprae bacilli within capillary endothelium. In contrast, gammadelta+ cells were decreased in or absent from the blood. Tumour necrosis factor-alpha and interleukin-6 were raised in the serum of the patients at the onset of the reaction. After the episode, cytokine levels and the percentage of gammadelta+ cells in the blood returned to normal. These cases characterize an uncommon leprotic reaction with clinical similarities to type II reaction and may indicate a significant role for gammadelta+ T cells in its pathogenesis. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Departamento de Patologia e Laboratórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Memorial Sloan-Kettering Cancer Center. Department of Pathology. New York, NY, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Patologia e Laboratórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Departamento de Patologia e Laboratórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | lepromatous leprosy | pt_BR |
Subject | type II reaction | pt_BR |
Subject | immunological aspects | pt_BR |
Subject | clinical aspects | pt_BR |
Subject | histological aspects | pt_BR |
e-ISSN | 1365-2230 | |
Embargo date | 2030-01-01 | |