| Author | Henrique-Pons, Andrea | |
| Author | Nagaraju, Kanneboyina | |
| Access date | 2018-09-21T18:50:49Z | |
| Available date | 2018-09-21T18:50:49Z | |
| Document date | 2009 | |
| Citation | PONS, Andrea Henriques; NAGARAJU, Kannenboyina. Non-immune mechanisms of muscle damage in myositis: Role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis. Curr Opin Rheumatol., v21, n.6, p.581-587, Nov. 2009. | pt_BR |
| ISSN | 1040-8711 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28975 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | retículo endoplasmático | pt_BR |
| Subject in Portuguese | miopatia idiopática | pt_BR |
| Subject in Portuguese | músculo esquelético | pt_BR |
| Subject in Portuguese | morte celular | pt_BR |
| Subject in Portuguese | autofagia | pt_BR |
| Title | Non-immune mechanisms of muscle damage in myositis: Role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis | pt_BR |
| Type | Article | |
| DOI | 10.1097/BOR.0b013e328331926 | |
| Abstract | Purpose of review—Recent literature in inflammatory myopathies suggests that both immune (cell-mediated and humoral) and non-immune (endoplasmic reticulum (ER) stress and autophagy) mechanisms play a role in muscle fiber damage and dysfunction. This review describes these findings and discusses their relevance to disease pathogenesis and therapy. Recent findings—Recent data highlights the role of ER stress response especially the roles of Hexose-6-phosphate dehydrogenase and ER-anchored RING finger E3 ligase in the activation of unfolded protein response and the formation of vacuoles and inclusions in myopathies. Several studies investigated the link between inflammation and the beta amyloid associated muscle fiber degeneration and loss of muscle function. Likewise, the roles of ER stress and autophagy in skeletal muscle damage have been explored in multiple muscle diseases. Summary—Current data indicate that the ER stress, NF-kB pathway and autophagy are active in the skeletal muscle of myositis patients, and the pro-inflammatory NF-kB pathway connects the immune and non-immune pathways of muscle damage. The relative contributions of each of these pathways to muscle fiber damage are presently unclear. Therefore further defining the role of these pathways in disease pathogenesis should help to design effective therapeutic agents for these diseases. | pt_BR |
| Affilliation | Children's National Medical Center. Dept. of Genetic Medicine. Washington, DC, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.l | pt_BR |
| Affilliation | Children's National Medical Center. Dept. of Genetic Medicine. Washington, DC, USA. | pt_BR |
| Subject | endoplasmic reticulum | pt_BR |
| Subject | idiopathic myopathy | pt_BR |
| Subject | skeletal muscle | pt_BR |
| Subject | cell death | pt_BR |
| Subject | autophagy | pt_BR |
| Subject | NF-kB | pt_BR |
| e-ISSN | 1531-6963 | |
| Embargo date | 2030-01-01 | |
