| Author | Villena, Suellen N. | |
| Author | Pinheiro, Roberta O. | |
| Author | Pinheiro, Carla S. | |
| Author | Nunes, Marise P. | |
| Author | Takiya, Cristina M. | |
| Author | Reis, George A. dos | |
| Author | Previato, José O. | |
| Author | Mendonça-Previato, Lucia | |
| Author | Lima, Célio G. Freire de | |
| Access date | 2018-09-22T17:06:36Z | |
| Available date | 2018-09-22T17:06:36Z | |
| Document date | 2008 | |
| Citation | VILENA, Suellen N. et al. Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand. Cellular Microbiology, v.10, n.6, p.1274-1285, 2008. | pt_BR |
| ISSN | 1462-5814 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28988 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Polissacarídeos capsulares | pt_BR |
| Subject in Portuguese | apoptose macrofágica | pt_BR |
| Subject in Portuguese | Cryptococcus neoformans | pt_BR |
| Subject in Portuguese | Proteína Ligante Fas | pt_BR |
| Title | Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1462-5822.2008.01125.x | |
| Abstract | The effects of capsular polysaccharides, galactoxylomannan (GalXM) and glucuronoxylomannan (GXM), from acapsular (GXM negative) and encapsulate strains of Cryptococcus neoformans were investigated in RAW 264.7 and peritoneal macrophages. Here, we demonstrate that GalXM and GXM induced different cytokines profiles in RAW 264.7 macrophages. GalXM induced production of TNF-alpha, NO and iNOS expression, while GXM predominantly induced TGF-beta secretion. Both GalXM and GXM induced early morphological changes identified as autophagy and late macrophages apoptosis mediated by Fas/FasL interaction, a previously unidentified mechanism of virulence. GalXM was more potent than GXM at induction of Fas/FasL expression and apoptosis on macrophages in vitro and in vivo. These findings uncover a mechanism by which capsular polysaccharides from C. neoformans might compromise host immune responses. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Capsular polysaccharides | pt_BR |
| Subject | Cryptococcus neoformans | pt_BR |
| Subject | macrophage apoptosis | pt_BR |
| Subject | Fas ligand | pt_BR |
| e-ISSN | 1462-5822 | |
| Embargo date | 2030-01-01 | |
